The Effects of Aspartame on Appetite, Body Composition and Oral Glucose Tolerance
- Conditions
- Oral Glucose Tolerance
- Interventions
- Other: waterOther: aspartame
- Registration Number
- NCT02999321
- Lead Sponsor
- Purdue University
- Brief Summary
Assess the impact of chronic use of aspartame on glycemia, appetite and body composition.
- Detailed Description
Participants will be randomly assigned to one of three parallel arms: 0% (water), 5 mg, 15mg aspartame. Participants will have an oral glucose tolerance test at the beginning and end of a 12 week intervention. . Participants will report to the lab weekly for 12 weeks to pick up their next week's intervention products and measurements for body weight, waist circumference, blood pressure and heart rate. They will consume their intervention products daily for 12 weeks. They will record appetite sensations and collect a 24 hour urine sample at weeks 0, 4, 8, and 12.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 93
- BMI 18-25
- Fasting blood sugar between 72 and 108 mg/dl via capillary finger-stick.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 0% aspartame (water) water participants will not have any aspartame, this is a control. 5 mg aspartame aspartame participants will receive 5 mg aspartame in a beverage. 15mg aspartame aspartame participants will receive 5 mg aspartame in a beverage, and 10mg in capsules.
- Primary Outcome Measures
Name Time Method change oral glucose tolerance week 12 4 hours sample taken at time point 240 minutes post glucola
- Secondary Outcome Measures
Name Time Method Appetite every hour for 1 day at week 12 questionnaire on hunger, fullness, desire to eat, prospective consumption, thirst taken hourly for one day
Body composition week 12 body composition measurement Plysmography (BOD POD)
Trial Locations
- Locations (1)
Purdue Univeristy
🇺🇸West Lafayette, Indiana, United States