The Effects of Aspartame on Appetite, Body Composition and Oral Glucose Tolerance
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 93
- 试验地点
- 2
- 主要终点
- change oral glucose tolerance
研究概览
简要总结
Assess the impact of chronic use of aspartame on glycemia, appetite and body composition.
详细描述
Participants will be randomly assigned to one of three parallel arms: 0% (water), 5 mg, 15mg aspartame. Participants will have an oral glucose tolerance test at the beginning and end of a 12 week intervention. . Participants will report to the lab weekly for 12 weeks to pick up their next week's intervention products and measurements for body weight, waist circumference, blood pressure and heart rate. They will consume their intervention products daily for 12 weeks. They will record appetite sensations and collect a 24 hour urine sample at weeks 0, 4, 8, and 12.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI 18-25
- •Fasting blood sugar between 72 and 108 mg/dl via capillary finger-stick.
排除标准
- 未提供
研究组 & 干预措施
0% aspartame (water)
participants will not have any aspartame, this is a control.
干预措施: water (Other)
15mg aspartame
participants will receive 5 mg aspartame in a beverage, and 10mg in capsules.
干预措施: aspartame (Other)
5 mg aspartame
participants will receive 5 mg aspartame in a beverage.
干预措施: aspartame (Other)
结局指标
主要结局
change oral glucose tolerance
时间窗: week 12 4 hours
sample taken at time point 0
次要结局
- Appetite(every hour for 1 day at week 12)
- Body composition(week 12)
研究者
Richard Mattes
Professor of Nutrition Sciences
Purdue University