Assessment of Autonomic nervous system in patients with neurosurgical problems

Completed

• Conditions: Cervical myelopathy, anuerysmal sub arachnoid hemorrhage, craniopharyngioma, hydrocephalus, posterior fossa and supratentorial tumour

• Registration Number: CTRI/2012/07/002788
• Lead Sponsor: National Institute Of mental Health and Neuro Sciences

Brief Summary

Autonomic nervous system reflexly controls the vital functions of the human body and is controlled by the higher centers in the brain. Lesions in these pathways can result in increased morbidity and mortality of these patients undergoing surgery under anesthesia. Assessment of this system by means of heart rate variability will provide insight into the functioning of the autonomic nervous system and can be used to optimize patient care. Adult patients undergoing surgery for cervical myelopathy, supratentorial and infratentorial tumors, and subarachnoid hemorrhage will be recruited for the project. Five minute recordings of ECG will be done either before or on the day of surgery using surface electrodes. R-R interval will be calculated using proprietary software. With this data, both linear and non models would be used to derive various parameters of heart rate variability. This would be correlated with intraoperative hemodynamic instability and condition of patients at discharge.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01-09
• Study Completion: 2016-01-07
• Last Update Posted: 2018-03-29

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 240

Inclusion Criteria

• Males or females ≥ 18 years Patients requiring surgery for Cervical spine pathologies, Posterior fossa and supratentorial tumors, Hydrocephalus, Craniopharyngiomas, subarachnoid hemorrhage.
• Patients undergoing lumbar spine surgeries (reference group).

Exclusion Criteria

•Patients having cardiac pacemaker, abnormal rhythms •Patients on beta blocker therapy.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
•Heart rate variability measured in terms of time domain, frequency domain and non linear model	•24 hours prior to surgery

Secondary Outcome Measures

Name	Time	Method
•Incidence of heart rate changes (±20%) and blood pressure changes (±20%).

Trial Locations

Locations (1)

National Institute of Mental Health and Neuro Sciences (NIMHANS); 🇮🇳 Bangalore, KARNATAKA, India

National Institute of Mental Health and Neuro Sciences (NIMHANS)

🇮🇳Bangalore, KARNATAKA, India

Dr M Radhakrishnan

Principal investigator

09632589296

mrks1974@yahoo.com