Heart rate variability as a tool to assess autonomic nervous system in patients with neurosurgical disorders.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 240
- 试验地点
- 1
- 主要终点
- •Heart rate variability measured in terms of time domain, frequency domain and non linear model
研究概览
简要总结
Autonomic nervous system reflexly controls the vital functions of the human body and is controlled by the higher centers in the brain. Lesions in these pathways can result in increased morbidity and mortality of these patients undergoing surgery under anesthesia. Assessment of this system by means of heart rate variability will provide insight into the functioning of the autonomic nervous system and can be used to optimize patient care. Adult patients undergoing surgery for cervical myelopathy, supratentorial and infratentorial tumors, and subarachnoid hemorrhage will be recruited for the project. Five minute recordings of ECG will be done either before or on the day of surgery using surface electrodes. R-R interval will be calculated using proprietary software. With this data, both linear and non models would be used to derive various parameters of heart rate variability. This would be correlated with intraoperative hemodynamic instability and condition of patients at discharge.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Males or females ≥ 18 years Patients requiring surgery for Cervical spine pathologies, Posterior fossa and supratentorial tumors, Hydrocephalus, Craniopharyngiomas, subarachnoid hemorrhage.
- •Patients undergoing lumbar spine surgeries (reference group).
排除标准
- •â€¢Patients having cardiac pacemaker, abnormal rhythms •Patients on beta blocker therapy.
结局指标
主要结局
•Heart rate variability measured in terms of time domain, frequency domain and non linear model
时间窗: •24 hours prior to surgery
次要结局
- •Incidence of heart rate changes (±20%) and blood pressure changes (±20%).