Stress Reactivity of Physical Stressor on Depression

Not Applicable

Completed

• Conditions: Depression
• Interventions: Other: Physical exercise

• Registration Number: NCT01791023
• Lead Sponsor: Universidade Federal do Rio de Janeiro

Brief Summary

Depressive elderly individuals have showed higher basal level of cortisol and lower level of dehydroepiandrosterone (DHEA). Moreover, changes on these hormone levels have also observed in reactivity of an acute stress, such as physical exercise. On the other hand, physical training can modulate the release of these hormones. Therefore, depressive elderly individuals physically actives might show attenuated reactivity of an acute physical stressor compared to sedentary elderly individuals. The aim of these study is to compare the effect of an acute physical stressor on cortisol levels in depressive and healthy individuals, physically actives and sedentaries. Additionally, the sulfated form of DHEA (DHEAS) serves as a reservoir for DHEA, because of that it is expected that DHEAS levels might reduce after the acute physical exercise.

Detailed Description

Depressive and healthy individuals were submitted to one session of 30 minutes of physical exercise of moderate intensity. Before and soon after the exercise it was collected saliva - to analyse cortisol and DHEAS hormones - and some psychological and physical aspects were also collected, such as anamneses, scales of anxiety, temperaments, mood, stress and quality of life. Moreover, during exercise heart rate and mood scale were assessed. To evaluate the reactivity and recovery of physical stressor (physical exercise) saliva tubes and psychological scales were collected 30 minutes and 45 minutes after the end of exercise.

Study Timeline

• Study Start: 2011-03
• Primary Completion: 2012-08
• Study Completion: 2012-12
• Study First Submitted: 2013-01-04
• Status Verified: 2013-02
• Study First Submitted QC: 2013-02-09
• Last Update Submitted: 2013-02-09
• Study First Posted: 2013-02-13
• Last Update Posted: 2013-02-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Age above of 60 years old
• Clinical diagnostic of depression

Exclusion Criteria

• Hormonal replacement
• Physical disease
• Fasting

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Physical exercise	Physical exercise	Physical exercise

Primary Outcome Measures

Name	Time	Method
Changes from baseline in cortisol and DHEAS levels to after an acute session of exercise	From before and to after one session of 30 minutes of exercise.

Trial Locations

Locations (1)

Deolindo Couto Neurology Institute; 🇧🇷 Rio de Janeiro, RJ, Brazil