Memory for Action in Neurological Patients

Not Applicable

Terminated

• Conditions: Alzheimer Disease; Parkinson Disease

• Registration Number: NCT02844855
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

Memory for action is especially important in everyday life although current literature is not very abundant. The enactment effect (i.e. better memory for performed actions than for verbally encoded sentences) is usually described as a robust effect in aging and can be found in many diseases. Although the enactment effect has been studied for three decades, there is still no consensus on how it enhances memory. Therefore, in order to gain additional insight into the representational basis of the enactment effect, in the present study, the investigators propose to test neurological patients. The investigators suggested that memory for action should be better than memory for verbally encoded information in Alzheimer's disease and Parkinson's disease.

If patients with Alzheimer's disease (AD) and Parkinson's disease (PD) have no cognitive assessment during the last 6 months, then they will realize different tests: MMSE (1), HAD (2), a cognitive assessment (3); (4); BREF (5); Assessment of apraxia, (6). Controls will perform the same tests to verify that they have no cognitive impairment. Then, two experimental conditions will be presented in all patients and controls: a first in which participants will have to name drawings (verbal learning) and a second in which they will have to reproduce an action associated with drawings (action learning). Immediately after this learning phase, a recognition task will be available and therefore participants will have to recognize drawings that had been presented previously. The main criteria used in the statistical analysis will be the correct recognition score.

Detailed Description

1. = Folstein et al., 1975,

2. = Zigmond \& Snaith, 1983,

3. = Dubois et al., 2002;

4. = Godefroy et al., 2008;

5. = Dubois et Pillon, 2000;

6. = Mahieux-Laurent, 2009.

Study Timeline

• Study First Submitted: 2016-07-22
• Study First Submitted QC: 2016-07-22
• Study First Posted: 2016-07-26
• Study Start: 2016-12-26
• Primary Completion: 2020-02-21
• Study Completion: 2020-02-21
• Status Verified: 2020-09
• Last Update Submitted: 2020-09-16
• Last Update Posted: 2020-09-17

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 83

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Number of correct answers	Day 1	The gain provided by the verbal learning vs action learning (number of correct answers).

Trial Locations

Locations (2)

CHU de Saint-Etienne; 🇫🇷 Saint-Etienne, France

Hcl - Cm2R; 🇫🇷 Villeurbanne, France