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临床试验/NCT02844855
NCT02844855终止不适用

Memory for Action in Neurological Patients

Centre Hospitalier Universitaire de Saint Etienne3 个研究点 分布在 1 个国家目标入组 83 人开始时间: 2016年12月26日最近更新:
适应症

试验速览

阶段
不适用
状态
终止
入组人数
83
试验地点
3
主要终点
Number of correct answers

研究概览

简要总结

Memory for action is especially important in everyday life although current literature is not very abundant. The enactment effect (i.e. better memory for performed actions than for verbally encoded sentences) is usually described as a robust effect in aging and can be found in many diseases. Although the enactment effect has been studied for three decades, there is still no consensus on how it enhances memory. Therefore, in order to gain additional insight into the representational basis of the enactment effect, in the present study, the investigators propose to test neurological patients. The investigators suggested that memory for action should be better than memory for verbally encoded information in Alzheimer's disease and Parkinson's disease.

If patients with Alzheimer's disease (AD) and Parkinson's disease (PD) have no cognitive assessment during the last 6 months, then they will realize different tests: MMSE (1), HAD (2), a cognitive assessment (3); (4); BREF (5); Assessment of apraxia, (6). Controls will perform the same tests to verify that they have no cognitive impairment. Then, two experimental conditions will be presented in all patients and controls: a first in which participants will have to name drawings (verbal learning) and a second in which they will have to reproduce an action associated with drawings (action learning). Immediately after this learning phase, a recognition task will be available and therefore participants will have to recognize drawings that had been presented previously. The main criteria used in the statistical analysis will be the correct recognition score.

详细描述

  1. = Folstein et al., 1975,
  2. = Zigmond & Snaith, 1983,
  3. = Dubois et al., 2002;
  4. = Godefroy et al., 2008;
  5. = Dubois et Pillon, 2000;
  6. = Mahieux-Laurent, 2009.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Single Group
主要目的
Basic Science
盲法
None

入排标准

年龄范围
55 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 未提供

排除标准

  • 未提供

结局指标

主要结局

Number of correct answers

时间窗: Day 1

The gain provided by the verbal learning vs action learning (number of correct answers).

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (3)

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Memory for Action in Neurological Patients | 临床试验