Myocardial protection in cardiac surgery
Phase 3
- Conditions
- Cardiopulmonary bypass.Nonrheumatic mitral valve disorder, unspecifiedI34.9
- Registration Number
- IRCT20191024045227N1
- Lead Sponsor
- Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 74
Inclusion Criteria
• Patients undergoing elective (first) mitral valve replacement or repair surgery for the first time • Patients with cardiopulmonary bypass who need cardiac arrest (cross-clamp and cardioplegia injection) • Age 22 - 72 years • EF equal or more than 40% preoperative • CPB time more than 60 min and less than 120 min • Having elective surgical consent • pulmonary artery pressure less than or equal to 50 mmHg preoperatively
Exclusion Criteria
• Previous Cardiac Surgery (Recurrent Patients)
• EF less than 40%
• pulmonary artery pressure more than 50 mmhg
• Ventricular hypertrophy
• Need for medication support (receiving inotropes before starting cardiac surgery)
• Having a pacemaker or implantable cardioverter/defibrillator (ICD)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Myocardial function. Timepoint: 1- pre operation 2 - post cardiopulmonary bypass 3 - post ICU 4 - post ICU. Method of measurement: 1- Echocardiography.;- ICU stay. Timepoint: Time to transfer the patient from the ICU to the post-ICU care unit. Method of measurement: Day of ICU stay.
- Secondary Outcome Measures
Name Time Method