A clinical trial to study the cardioprotective effect of remote ischemic preconditioning in acute coronary syndrome patients
Not Applicable
- Conditions
- Health Condition 1: I228- Subsequent ST elevation (STEMI) myocardial infarction of other sites
- Registration Number
- CTRI/2023/10/058663
- Lead Sponsor
- Department of Health Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
(1) All ACS patients with STEMI/NSTEMI enrolled for stent implantation
(2) Age > 18 years.
(3) Gender: Both M and F
Exclusion Criteria
(1) Patients below 18 years
(2) Coronary artery bypass grafting (CABG) patients
(3) Patients with permanent pacemaker
(4) Patients with a Left Bundle Branch block on electrocardiogram
(5) Patients with cardiogenic shock
(6) Breastfeeding or pregnant women
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Difference in the levels of cardiac biomarkers, inflammatory markers (IL-6, IL-8, IL-10, IL-33, CRP, IFN gamma) and vitamin D before and 24 hours after PCI in control and RIPC arm.Timepoint: At the time of enrolment and 24 hours post PCI.
- Secondary Outcome Measures
Name Time Method Comparison of the following outcomes between the RIPC & control arm: <br/ ><br>1. Difference in survival at 30 days <br/ ><br>2. Difference in non-fatal MACE at 30 day <br/ ><br>3. Measurement of Ejection fraction, end diastolic volume, end systolic volume, WMSI, RWMA at 30 days following primary PCI <br/ ><br>Timepoint: 30 days after enrollment