Study on the protective effect of remote ischemic preconditioning against acute kidney injury induced by repeated use of tourniquets in the extremity surgery
Not Applicable
- Conditions
- Reapplying tourniquets during surgery
- Registration Number
- ChiCTR2400088778
- Lead Sponsor
- Department of Anesthesiology, No. 988 Hospital of Logistic Support Force of PLA
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
?For patients undergoing general anesthesia for extremity surgery, tourniquets were applied twice and each time was > 40min. ?Age 20-50 years old. ?BMI 20-30kg/m2. ?ASA grades I-II.
Exclusion Criteria
? Patients with underlying diseases such as diabetes and hypertension. ? Patients with preoperative vascular lesions involving upper limbs. ? Patients with mental system diseases.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Insulin-like growth factor-binding protein-7 (IGFBP-7);Neutrophil gelatinase-associated lipocalin (NGAL);
- Secondary Outcome Measures
Name Time Method Tissue inhibitor of metalloproteinases-2 (TIMP-2);Kidney Injury Molecule-1 (KIM-1); Interleukin-18 (IL-18);Serum cystatin-C (Cys-C) ;Blood Urea Nitrogen (BUN);Serum creatinine (SCr) ;Malondialdehyde(MDA);Superoxide dismutase (SOD);