Effects of remote ischemic conditioning on near and long term outcomes in patients undergoing aortic surgery: a randomized, controlled, double-blind trial
- Conditions
- Aortic disease
- Registration Number
- ChiCTR2400088830
- Lead Sponsor
- Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
- Over 18 years of age;<br>2) Patients undergoing elective or emergency aortic surgery;<br>3) Sign a written informed consent.
Exclusion Criteria<br>1) Under 18 years of age;<br>2) Symptomatic upper limb atherosclerosis, previous upper limb venous thrombosis, or history of axillary vascular surgery;<br>3) lactation or pregnancy;<br>4) Cardiac arrest on admission;<br>5) Severe liver dysfunction (international normalized ratio > 2);<br>6) History of malignant tumor;<br>7) Severe lung disease (predicted forced expiratory volume < 40% in 1 second), preoperative respiratory infection;<br>8) Previous renal failure, history of renal transplantation, and preoperative estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2;<br>9) Take glibenclamide or nicordil, as these drugs may interfere with RIPC;<br>10) Previous cerebral infarction, residual limb movement disorder, brain trauma, neurosurgery history<br>11) History of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis or dementia;<br>12) Being recruited into another study that could affect this study;<br>13) Those with other conditions deemed unsuitable for inclusion by the researchers.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method All-cause mortality during hospitalization;
- Secondary Outcome Measures
Name Time Method Myocardial infarction;Neurocognitive dysfunction;Pulmonary infection;Acute kidney injury;Mechanical circulation aid;