Effect of ischemic conditioning of thigh on neurologic and cardiac recovery in out-of-hospital cardiac arrest

Not Applicable

• Conditions: Diseases of the circulatory system

• Registration Number: KCT0002287
• Lead Sponsor: Chonnam National University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 March 2019

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 118

Inclusion Criteria

adult greater than 19 years old
out-of-hospital cardiac arrest with sustained restoration of spontaenous circulation
comatose following restoration of spontaenous circulation
time of enrollment within 6 hours from restoration of spontaneous circulation
undergoing targeted temperature management
cardiac arrest from medical cause (cardiac or other medical cause)

Exclusion Criteria

1) Pre-existing dementia, brain injury, or dependence on others (cerebral performance category scale??3)
2) Traumatic etiology for cardiac arrest
3) Protected population (pregnant, prisoner)
4) in-hospital cardiac arrest
5) Known bleeding diathesis
6) suspected or confirmed acute intracranial hemorrhage
7) suspected or confirmed acute ischemic stroke
8) Known limitations in therapy and do-not-resuscitate order
9) known disease making 180-day survival unlikely
10) >6 hours from restoration of spontaneous circulation to randomization
11) cardiac arrest from asphyxia (hanging, foreign body airway obstruction), drowning, drug overdose, or electrocution
12) peripheral vascular disease (Deep vein thrombosis, arteriosclerosis obliterans)
13) systolic blood pressure < 80 mmHg in spite of fluid loading/vasopressor and/or inotropic medication

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
neuron specific enolase

Secondary Outcome Measures

Name	Time	Method
neurologic outcome at discharge