The excitability of peripheral nerves following acute stroke: A 6-month follow-up study using neurophysiological and clinical tests

Recruiting

• Conditions: cerebrovascular accident; stroke; 10007963

• Registration Number: NL-OMON34667
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 116

Inclusion Criteria

- A first-ever ischemic stroke
- Hemiplegia, including weakness of the hand muscles
- Stroke onset < 24 hours before the first recordings
- Stable vital signs

Exclusion Criteria

- Non stroke-related sensory or motor impairments
- Any peripheral lesion of the median nerve, such as nerve root compression syndrome, cervical spondylosis, carpal tunnel syndrome, or other peripheral neuropathy revealed by neurological examinations and electrodiagnostic tests
- Any history of other diseases or treatment that might have affected the peripheral nerve

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>For neurophysiology: estimates of the number of functioning motor units (MUNEs)<br /><br>and excitability variables obtained with threshold tracking techniques. For<br /><br>clinical stroke assessment: questionnaires (NIHSS) and scales (modified Rankin<br /><br>scale, Barthel index), CT, the TOAST classification of stroke subtype, and an<br /><br>evaluation of cardiovascular risk factors.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>N.v.t.</p><br>