Evaluation of Different Continuous Positive Airway Pressure (CPAP) Systems in Patients With Acute Respiratory Failure

Completed

• Conditions: Acute Respiratory Failure
• Interventions: Procedure: CPAP system

• Registration Number: NCT00876473
• Lead Sponsor: Policlinico Hospital

Brief Summary

The aim of this study is to evaluate the performance, the tolerability and the efficacy on gas-exchange of different CPAP (Continuous Positive Airway Pressure) systems.

Detailed Description

Three CPAP systems are studied for each patient at the same level of PEEP: 1) continuous high-flow CPAP with fixed value PEEP valve; 2) continuous high-flow CPAP with Boussignac PEEP valve; 3) demand flow CPAP, supplied by a ventilator.

Study Timeline

• Study Start: 2009-04
• Study First Submitted: 2009-04-03
• Study First Submitted QC: 2009-04-03
• Study First Posted: 2009-04-06
• Primary Completion: 2014-01
• Study Completion: 2014-01
• Status Verified: 2015-04
• Last Update Submitted: 2015-04-27
• Last Update Posted: 2015-04-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Intubated-tracheostomized subjects receiving CPAP during the weaning from invasive mechanical ventilation

Exclusion Criteria

• Hemodynamic instability
• Barotrauma
• Severe myopathy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
1	CPAP system	Acute Respiratory Failure patients

Primary Outcome Measures

Name	Time	Method
Respiratory mechanics, work of breathing, end-expiratory lung volume (EELV) and gas exchange	30 minutes

Secondary Outcome Measures

Name	Time	Method
Comfort of breathing	30 minutes

Trial Locations

Locations (1)

Policlinico Hospital; 🇮🇹 Milan, Italy