Effect of Bilateral Ultrasound Guided Quadratus Lumborum Block Versus Lumbar Epidural Block on Postoperative Analgesia, and Inflammatory Response Following Major Lower Abdominal Cancer Surgery
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- postoperative pain
研究概览
简要总结
This study aims at comparing the effects of bilateral ultrasound-guided quadratus lumborum block versus lumbar epidural block on postoperative analgesia and inflammatory response following major lower abdominal cancer surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA II, III
- •Weight 50 - 85 kg.
- •Scheduled for major lower abdominal cancer surgery (radical cystectomy, total abdominal hysterectomy).
排除标准
- •Patients with a history of relevant drug allergy.
- •Coagulation disorders.
- •Opioid dependence.
- •Local infection at the vicinity of the block site.
- •Patients with psychiatric illnesses that would interfere with perception and assessment of pain
研究组 & 干预措施
quadratus lumborum block
received pre-emptive ultrasound-guided quadratus lumborum block with 25 mL of 0.25% bupivacaine on each side of the abdominal wall before induction of GA.
干预措施: Ultrasound quadratus lumborum block with bupivacaine 25% (Other)
lumbar epideural block
received pre-emptive lumbar epidural block with 15 mL of 0.25% bupivacaine before induction of GA.
干预措施: lumbar epideural block with bupivacaine 25% (Other)
结局指标
主要结局
postoperative pain
时间窗: first 24 hours postoperatively
postoperative pain intensity.
次要结局
- side effects(first 24 hours postoperatively)
- postoperative inflammatory response(first 24 hours postoperatively)
研究者
Ahmad Mohammad Abd El-Rahman
assisstant professor of Anesthesia, ICU, and Pain Management
Assiut University