Quadratus Luborum Block Using Bupivacaine Versus Bupivacaine-Dexamethasone in Laparoscopic Cholecystectomy
- Conditions
- Post Operative Pain
- Interventions
- Drug: TQL block with salineDrug: TQL block with Bupivacaine
- Registration Number
- NCT03956966
- Lead Sponsor
- Minia University
- Brief Summary
The aim of the present study was to compare the effectiveness of transmuscular Quadratus Lumborum block using Bupivacaine versus Bupivacaine- Dexamethasone in providing analgesia in patients undergoing laparoscopic cholecystectomy.
Because postoperative pain after laparoscopic surgery is complex, specialists suggest that effective analgesic treatment should be a multimodal support. Quadratus lumborum block (QLB) is a new abdominal truncal block for controlling somatic pain in both the upper and lower abdomen. Dexamethasone, through its anti-inflammatory and blocking effects on neural discharge, and nociceptor C fibers transmission could be used as a local anesthetic adjuvant.
- Detailed Description
The patients were randomly allocated into three groups each contains (30) patient. Control group (C) received bilateral ultrasound guided quadratus lumborum block using (20 ml 0.9% normal saline + 1mL 0.9% normal saline) in each side ,Bupivacaine group (B) received bilateral quadratus lumborum block using (20 ml Bupivacaine hydrochloride 0.25% + 1mL 0.9% normal saline) in each side and Dexamethasone-Bupivacaine group (D) received bilateral quadratus lumborum block using (20 ml Bupivacaine hydrochloride 0.25% + 1 mL dexamethasone "4mg") in each side.
The following variables: heart Rate, mean arterial Blood Pressure, peripheral oxygen saturation, visual analogue pain scale , time to first analgesic request, total Analgesic requirement in the first 24 hours, patient satisfaction and complications were Recorded and compared between groups.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 90
- American Physical Status I or II
- Elective laparoscopic Cholecystectomy
- Patient refusal.
- Hematological diseases
- Bleeding disorders.
- Coagulation abnormality.
- Psychiatric diseases.
- Local skin infection
- Sepsis at site of the block.
- Known intolerance to the study drugs.
- Body Mass Index > 40 Kg/m2.
- Emergency laparoscopic cholecystectomy
- If laparoscopic procedure converted to open.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Bupivacaine and dexamethasone TQL block with Bupivacaine and dexamethasone bilateral quadratus lumborum block using Bupivacaine hydrochloride 0.25% and dexamethasone saline TQL block with saline bilateral quadratus lumborum block using 0.9% normal saline Bupivacaine TQL block with Bupivacaine bilateral quadratus lumborum block using Bupivacaine hydrochloride 0.25%
- Primary Outcome Measures
Name Time Method Time for first request to rescue analgesia 24 hours Time for the first request to rescue analgesia (in minutes)
- Secondary Outcome Measures
Name Time Method intraoperative fentanyl For 4 hours after start of anaesthesia Cumulative intraoperative fentanyl consumption (total dose given in micrograms)
side effects For 24 hours after surgery Incidence of postoperative nausea and vomiting
postoperative Nalbuphine 24 hours after surgery Cumulative postoperative Nalbuphine consumption (total dose given in milligrams)
Postoperative pain severity will be assessed using VAPS For 24 hours after surgery The severity of postoperative pain will be measured and recorded by using the visual analogue scale (VAPS) for pain, where 0 is equal to no pain and 10 indicates the worst possible pain
Trial Locations
- Locations (1)
Minya University
🇪🇬Minya, Egypt