Ultrasound-guided Quadratus Luborum Block Using Bupivacaine Versus Bupivacaine-Dexamethasone for Postoperative Analgesia in Laparoscopic Cholecystectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Time for first request to rescue analgesia
研究概览
简要总结
The aim of the present study was to compare the effectiveness of transmuscular Quadratus Lumborum block using Bupivacaine versus Bupivacaine- Dexamethasone in providing analgesia in patients undergoing laparoscopic cholecystectomy.
Because postoperative pain after laparoscopic surgery is complex, specialists suggest that effective analgesic treatment should be a multimodal support. Quadratus lumborum block (QLB) is a new abdominal truncal block for controlling somatic pain in both the upper and lower abdomen. Dexamethasone, through its anti-inflammatory and blocking effects on neural discharge, and nociceptor C fibers transmission could be used as a local anesthetic adjuvant.
详细描述
The patients were randomly allocated into three groups each contains (30) patient. Control group (C) received bilateral ultrasound guided quadratus lumborum block using (20 ml 0.9% normal saline + 1mL 0.9% normal saline) in each side ,Bupivacaine group (B) received bilateral quadratus lumborum block using (20 ml Bupivacaine hydrochloride 0.25% + 1mL 0.9% normal saline) in each side and Dexamethasone-Bupivacaine group (D) received bilateral quadratus lumborum block using (20 ml Bupivacaine hydrochloride 0.25% + 1 mL dexamethasone "4mg") in each side.
The following variables: heart Rate, mean arterial Blood Pressure, peripheral oxygen saturation, visual analogue pain scale , time to first analgesic request, total Analgesic requirement in the first 24 hours, patient satisfaction and complications were Recorded and compared between groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Physical Status I or II
- •Elective laparoscopic Cholecystectomy
排除标准
- •Patient refusal.
- •Hematological diseases
- •Bleeding disorders.
- •Coagulation abnormality.
- •Psychiatric diseases.
- •Local skin infection
- •Sepsis at site of the block.
- •Known intolerance to the study drugs.
- •Body Mass Index > 40 Kg/m
- •Emergency laparoscopic cholecystectomy
- •If laparoscopic procedure converted to open.
研究组 & 干预措施
saline
bilateral quadratus lumborum block using 0.9% normal saline
干预措施: TQL block with saline (Drug)
Bupivacaine
bilateral quadratus lumborum block using Bupivacaine hydrochloride 0.25%
干预措施: TQL block with Bupivacaine (Drug)
Bupivacaine and dexamethasone
bilateral quadratus lumborum block using Bupivacaine hydrochloride 0.25% and dexamethasone
干预措施: TQL block with Bupivacaine and dexamethasone (Drug)
结局指标
主要结局
Time for first request to rescue analgesia
时间窗: 24 hours
Time for the first request to rescue analgesia (in minutes)
次要结局
- intraoperative fentanyl(For 4 hours after start of anaesthesia)
- side effects(For 24 hours after surgery)
- postoperative Nalbuphine(24 hours after surgery)
- Postoperative pain severity will be assessed using VAPS(For 24 hours after surgery)
研究者
haidy salah mansour
principle investigator
Minia University