Bilateral Ultrasound Guided Quadratus Lumborum Versus Lumbar Epidural Block on Postoperative Analgesia, and Inflammatory Response in Abdominal Surgery

Not Applicable

• Conditions: Inflammatory Response; Postoperative Pain

• Registration Number: NCT03958942
• Lead Sponsor: Assiut University

Brief Summary

This study aims at comparing the effects of bilateral ultrasound-guided quadratus lumborum block versus lumbar epidural block on postoperative analgesia and inflammatory response following major lower abdominal cancer surgery.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-05-15
• Study First Submitted QC: 2019-05-20
• Study First Posted: 2019-05-22
• Study Start: 2019-06-01
• Status Verified: 2019-07
• Last Update Submitted: 2019-07-02
• Last Update Posted: 2019-07-05
• Primary Completion: 2020-01-01
• Study Completion: 2020-03-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• ASA II, III
• Weight 50 - 85 kg.
• Scheduled for major lower abdominal cancer surgery (radical cystectomy, total abdominal hysterectomy).

Exclusion Criteria

• Patients with a history of relevant drug allergy.
• Coagulation disorders.
• Opioid dependence.
• Sepsis.
• Local infection at the vicinity of the block site.
• Patients with psychiatric illnesses that would interfere with perception and assessment of pain

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
postoperative pain	first 24 hours postoperatively	postoperative pain intensity.

Secondary Outcome Measures

Name	Time	Method
side effects	first 24 hours postoperatively	sedation, nausea, vomiting, and respiratory depression
postoperative inflammatory response	first 24 hours postoperatively	inflammatory response represented by the levels of: interleukins 1,6, and tumor necrosis factor alpha

Trial Locations

Locations (1)

South Egypt Cancer Institute; 🇪🇬 Assiut, Egypt