Bilateral Ultrasound Guided Quadratus Lumborum Versus Lumbar Epidural Block on Postoperative Analgesia, and Inflammatory Response in Abdominal Surgery

Not Applicable

• Conditions: Inflammatory Response; Postoperative Pain
• Interventions: Other: Ultrasound quadratus lumborum block with bupivacaine 25%; Other: lumbar epideural block with bupivacaine 25%

• Registration Number: NCT03958942
• Lead Sponsor: Assiut University

Brief Summary

This study aims at comparing the effects of bilateral ultrasound-guided quadratus lumborum block versus lumbar epidural block on postoperative analgesia and inflammatory response following major lower abdominal cancer surgery.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-05-15
• Study First Submitted QC: 2019-05-20
• Study First Posted: 2019-05-22
• Study Start: 2019-06-01
• Status Verified: 2019-07
• Last Update Submitted: 2019-07-02
• Last Update Posted: 2019-07-05
• Primary Completion: 2020-01-01
• Study Completion: 2020-03-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• ASA II, III
• Weight 50 - 85 kg.
• Scheduled for major lower abdominal cancer surgery (radical cystectomy, total abdominal hysterectomy).

Exclusion Criteria

• Patients with a history of relevant drug allergy.
• Coagulation disorders.
• Opioid dependence.
• Sepsis.
• Local infection at the vicinity of the block site.
• Patients with psychiatric illnesses that would interfere with perception and assessment of pain

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
quadratus lumborum block	Ultrasound quadratus lumborum block with bupivacaine 25%	received pre-emptive ultrasound-guided quadratus lumborum block with 25 mL of 0.25% bupivacaine on each side of the abdominal wall before induction of GA.
lumbar epideural block	lumbar epideural block with bupivacaine 25%	received pre-emptive lumbar epidural block with 15 mL of 0.25% bupivacaine before induction of GA.

Primary Outcome Measures

Name	Time	Method
postoperative pain	first 24 hours postoperatively	postoperative pain intensity.

Secondary Outcome Measures

Name	Time	Method
side effects	first 24 hours postoperatively	sedation, nausea, vomiting, and respiratory depression
postoperative inflammatory response	first 24 hours postoperatively	inflammatory response represented by the levels of: interleukins 1,6, and tumor necrosis factor alpha

Trial Locations

Locations (1)

South Egypt Cancer Institute; 🇪🇬 Assiut, Egypt