Prolonged Cardiopulmonary Bypass Time as Predictive Factor for in Hospital Infection
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Bloodstream Infection (BSI)
- Sponsor
- University Hospital, Basel, Switzerland
- Enrollment
- 7064
- Locations
- 1
- Primary Endpoint
- Extracorporeal circulation time during surgery (minutes)
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
This study is to analyse the demographics and microbiological factors concerning patients undergoing cardio surgical intervention using CPB complicated with bloodstream infection (BSI) postoperatively.
Detailed Description
Infectious complications after cardiovascular surgery, especially in operations that use cardiopulmonary bypass (CPB), is associated with significant morbidity and increase in peri-operative mortality. Prolonged CPB usage could be predictive for early bloodstream infection following cardia surgery. This study is to analyse the demographics and microbiological factors concerning patients undergoing cardio surgical intervention using CPB complicated with bloodstream infection (BSI) postoperatively.
Investigators
Eligibility Criteria
Inclusion Criteria
- •adult patients undergoing cardiac surgery
Exclusion Criteria
- •patients having active or previous endocarditis
- •patients whose causative microorganism of postoperative BSI was identical to that isolated from preoperative or intraoperative samples
- •patients with common skin colonized microorganisms, such as coagulase-negative Staphylococci, Viridans group Streptococci, Corynebacterium species, Bacillus species, Propionibacterium species, and Aerococcus species or Micrococcus species, which were isolated from only a single blood sample and without evidence of clinical sepsis, because contamination was considered.
Outcomes
Primary Outcomes
Extracorporeal circulation time during surgery (minutes)
Time Frame: one time assessment at baseline
Extracorporeal circulation time during surgery (minutes)
In-hospital mortality (number) for patients with BSI vs those without BSI after a cardiovascular surgery
Time Frame: during hospital stay (usually up to 4 weeks)
In-hospital mortality is defined as death before discharge
Surgical intervention rate (Incidence of cardiovascular re-operation) during the initial hospital stay (number)
Time Frame: during hospital stay (usually up to 4 weeks)
Surgical intervention rate (Incidence of cardiovascular re-operation) during the initial hospital stay
Incidence of bloodstream infection (BSI) in postoperative period (clinical evidence of sepsis with laboratory-confirmed bacteraemia from blood sample)
Time Frame: within 7 days after a cardiovascular surgery
Incidence of bloodstream infection (BSI) in postoperative period (clinical evidence of sepsis with laboratory-confirmed bacteraemia from blood sample)
Secondary Outcomes
- Incidence of cardiovascular events (stroke, myocardial infarction) during hospitalization(during hospital stay (usually up to 4 weeks))
- Incidence of cardiovascular re-operation during the follow up(after hospital discharge until follow- up assessment (up to 10 years))
- Incidence of cardiovascular events (stroke, myocardial infarction) during follow-up(after hospital discharge until follow- up assessment (up to 10 years))