Prolonged Cardiopulmonary Bypass Time as Predictive Factor for in Hospital Infection
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 7,064
- 试验地点
- 1
- 主要终点
- Extracorporeal circulation time during surgery (minutes)
研究概览
简要总结
This study is to analyse the demographics and microbiological factors concerning patients undergoing cardio surgical intervention using CPB complicated with bloodstream infection (BSI) postoperatively.
详细描述
Infectious complications after cardiovascular surgery, especially in operations that use cardiopulmonary bypass (CPB), is associated with significant morbidity and increase in peri-operative mortality. Prolonged CPB usage could be predictive for early bloodstream infection following cardia surgery. This study is to analyse the demographics and microbiological factors concerning patients undergoing cardio surgical intervention using CPB complicated with bloodstream infection (BSI) postoperatively.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult patients undergoing cardiac surgery
排除标准
- •patients having active or previous endocarditis
- •patients whose causative microorganism of postoperative BSI was identical to that isolated from preoperative or intraoperative samples
- •patients with common skin colonized microorganisms, such as coagulase-negative Staphylococci, Viridans group Streptococci, Corynebacterium species, Bacillus species, Propionibacterium species, and Aerococcus species or Micrococcus species, which were isolated from only a single blood sample and without evidence of clinical sepsis, because contamination was considered.
结局指标
主要结局
Extracorporeal circulation time during surgery (minutes)
时间窗: one time assessment at baseline
Extracorporeal circulation time during surgery (minutes)
In-hospital mortality (number) for patients with BSI vs those without BSI after a cardiovascular surgery
时间窗: during hospital stay (usually up to 4 weeks)
In-hospital mortality is defined as death before discharge
Surgical intervention rate (Incidence of cardiovascular re-operation) during the initial hospital stay (number)
时间窗: during hospital stay (usually up to 4 weeks)
Surgical intervention rate (Incidence of cardiovascular re-operation) during the initial hospital stay
Incidence of bloodstream infection (BSI) in postoperative period (clinical evidence of sepsis with laboratory-confirmed bacteraemia from blood sample)
时间窗: within 7 days after a cardiovascular surgery
Incidence of bloodstream infection (BSI) in postoperative period (clinical evidence of sepsis with laboratory-confirmed bacteraemia from blood sample)
次要结局
- Incidence of cardiovascular events (stroke, myocardial infarction) during hospitalization(during hospital stay (usually up to 4 weeks))
- Incidence of cardiovascular re-operation during the follow up(after hospital discharge until follow- up assessment (up to 10 years))
- Incidence of cardiovascular events (stroke, myocardial infarction) during follow-up(after hospital discharge until follow- up assessment (up to 10 years))