Prolonged Cardiopulmonary Bypass (CPB) Time as a Predictive Factor for Acute Gastrointestinal Injury (AGI) After Heart Valve Replacement
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,070
- 试验地点
- 1
- 主要终点
- Cardiopulmonary bypass (CPB) time
研究概览
简要总结
In this retrospective study, the investigators will analyze the correlation between cardiopulmonary bypass (CPB) time and acute gastrointestinal injury (AGI), and the outcomes of AGI in patients undergoing heart valve replacement.
详细描述
Patients with heart valve diseases often have chronic cardiac insufficiency. Patients undergoing heart valve replacement with CPB are always complicated with gastrointestinal tract ischemia-reperfusion injury, which usually leads to AGI. AGI after cardiovascular surgery, especially in that use CPB, is associated with significant morbidity and an increase in peri-operative mortality. Prolonged CPB time could be predictive of AGI following heart valve replacement. This study is to analyze the correlation between CPB time and AGI, and the outcomes of AGI in patients undergoing heart valve replacement. The investigators hope that the benefits will include fewer patients becoming seriously postoperative AGI and mortality after cardiac surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing heart valve replacement surgery with CPB
- •Age > 18 years and ≤ 70 years
排除标准
- •Patients combined with severe hematological disease, respiratory disease, and other critical diseases
- •Patients had severe disorder of multiple systems and organs or severe pulmonary hypertension
- •Have received major gastrointestinal surgery within 5 years
- •Inflammatory bowel disease (IBD), including ulcerative colitis, Crohn's disease, or colitis
- •Acute gastroenteritis
- •Clostridium difficile or Helicobacter pylori infection
- •Chronic constipation
- •Peptic ulcer
- •Polyps in the stomach or intestines
- •Gastrointestinal neoplasms
- •Abdominal hernia
- •Irritable bowel syndrome
- •Acute or chronic cholecystitis, hepatitis
- •Patients who died during surgery
- •Patients with digestive system tumors
结局指标
主要结局
Cardiopulmonary bypass (CPB) time
时间窗: 1 month
Was defined it as the sum of times of CPB during surgery (minutes).
The AGI score
时间窗: 1 month
The AGI score of the patient within the seventh postoperative day was performed according to the European Society of critical care (2012) guidelines for AGI.
次要结局
- Number of bowel sounds(1 month)
- Proportion of cocci and bacilli in feces(1 month)
- First defecation time(1 month)
- Alanine aminotransferase (ALT)(1 month)
- Aspartate aminotransferase (AST)(1 month)
- Left ventricular ejection fraction (LVEF)(1 month)
研究者
Wenbo Meng
Professor of Surgery
Hepatopancreatobiliary Surgery Institute of Gansu Province