Prolonged Cardiopulmonary Bypass (CPB) Time as a Predictive Factor for Acute Gastrointestinal Injury (AGI) After Heart Valve Replacement
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Valve Diseases
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
- Enrollment
- 1070
- Locations
- 1
- Primary Endpoint
- Cardiopulmonary bypass (CPB) time
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
In this retrospective study, the investigators will analyze the correlation between cardiopulmonary bypass (CPB) time and acute gastrointestinal injury (AGI), and the outcomes of AGI in patients undergoing heart valve replacement.
Detailed Description
Patients with heart valve diseases often have chronic cardiac insufficiency. Patients undergoing heart valve replacement with CPB are always complicated with gastrointestinal tract ischemia-reperfusion injury, which usually leads to AGI. AGI after cardiovascular surgery, especially in that use CPB, is associated with significant morbidity and an increase in peri-operative mortality. Prolonged CPB time could be predictive of AGI following heart valve replacement. This study is to analyze the correlation between CPB time and AGI, and the outcomes of AGI in patients undergoing heart valve replacement. The investigators hope that the benefits will include fewer patients becoming seriously postoperative AGI and mortality after cardiac surgery.
Investigators
Wenbo Meng
Professor of Surgery
Hepatopancreatobiliary Surgery Institute of Gansu Province
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing heart valve replacement surgery with CPB
- •Age \> 18 years and ≤ 70 years
Exclusion Criteria
- •Patients combined with severe hematological disease, respiratory disease, and other critical diseases
- •Patients had severe disorder of multiple systems and organs or severe pulmonary hypertension
- •Have received major gastrointestinal surgery within 5 years
- •Inflammatory bowel disease (IBD), including ulcerative colitis, Crohn's disease, or colitis
- •Acute gastroenteritis
- •Clostridium difficile or Helicobacter pylori infection
- •Chronic constipation
- •Peptic ulcer
- •Polyps in the stomach or intestines
- •Gastrointestinal neoplasms
Outcomes
Primary Outcomes
Cardiopulmonary bypass (CPB) time
Time Frame: 1 month
Was defined it as the sum of times of CPB during surgery (minutes).
The AGI score
Time Frame: 1 month
The AGI score of the patient within the seventh postoperative day was performed according to the European Society of critical care (2012) guidelines for AGI.
Secondary Outcomes
- Number of bowel sounds(1 month)
- Proportion of cocci and bacilli in feces(1 month)
- First defecation time(1 month)
- Alanine aminotransferase (ALT)(1 month)
- Aspartate aminotransferase (AST)(1 month)
- Left ventricular ejection fraction (LVEF)(1 month)