Metabolomic study in head and neck cancer patients receiving concurrent chemoradiotherapy (CCRT) and Hydrogen gas inhalation: Pilot study
Phase 2
- Conditions
- The serum metabolome in 2 groups of locally advanced head and neck cancer patients who will be treated with CCRT plus H2 gas inhalation versus CCRT alone.Metabolome, Metabolomic, Hydrogen gas, Hydrogen gas Inhalation, Concurrent chemoradiotherapy, Locally advanced head and neck cancer
- Registration Number
- TCTR20240515006
- Lead Sponsor
- Faculty of Medicine, Chiang Mai University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Enrolling by invitation
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Loco-regional advanced stage HNC.
Histologically-proven diagnosis of HNC.
Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
Able to provide informed consent.
Exclusion Criteria
Distant metastasis or locoregional recurrence disease.
Contraindications to RT or chemotherapy or Hydrogen gas inhalation.
Previous head and neck irradiation.
Patients with tracheostomy tube.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Metabolome Before and end of CCRT. The proton NMR spectrum will be recorded and acquired using a Bruker AVANCE 500 MHz instrument.
- Secondary Outcome Measures
Name Time Method Safety of hydrogen gas inhalation During CCRT Descriptive