Mechanisms of Arm Recovery in Stroke Patients With Hand Paralysis

Not Applicable

Completed

• Conditions: Stroke; Cerebral Vascular Accident; Hemiparesis; Stroke, Ischemic
• Interventions: Procedure: Affected Transcranial Magnetic Stimulation; Procedure: Control Transcranial Magnetic Stimulation; Procedure: Unaffected Transcranial Magnetic Stimulation

• Registration Number: NCT03067818
• Lead Sponsor: George Mason University

Brief Summary

This study examines the effect of non-invasive brain stimulation targeting different brain areas on movement of the affected arm post-stroke. Participants will receive stimulation to each of 3 different brain areas combined with a session of arm exercise.

Detailed Description

Small improvements in affected arm movement can be made with intensive physical practice. These improvements could potentially be enhanced by combining non-invasive brain stimulation with practice.

To develop such an intervention, it is necessary to understand which brain areas should be stimulated in which types of patients. It is probably more beneficial to target one side of the brain vs. the other, for example, depending on the characteristics of the stroke.

This study will examine the effect of stimulating one side of the brain vs. the other on the amount of improvement that occurs from physically practicing functional arm movements.

Study Timeline

• Study First Submitted: 2017-02-24
• Study First Submitted QC: 2017-02-24
• Study First Posted: 2017-03-01
• Study Start: 2017-06-20
• Primary Completion: 2019-08-15
• Study Completion: 2019-08-28
• Status Verified: 2019-09
• Last Update Submitted: 2019-09-10
• Last Update Posted: 2019-09-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• More than 6 months post-stroke
• Loss of voluntary finger movement in the affected hand
• Some voluntary movement of affected shoulder and/or elbow

Exclusion Criteria

• Brainstem or cerebellar stroke
• Severe cognitive or language deficits
• Epilepsy or other seizure disorder
• Central nervous system disease or disorder other than stroke

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Affected Hemisphere	Affected Transcranial Magnetic Stimulation	Application of "Affected Transcranial Magnetic Stimulation" to affected hemisphere site prior to physical practice
Control Site	Control Transcranial Magnetic Stimulation	Application of "Control Transcranial Magnetic Stimulation" to control site prior to practice
Unaffected Hemisphere	Unaffected Transcranial Magnetic Stimulation	Application of "Unaffected Transcranial Magnetic Stimulation" to unaffected hemisphere site prior to physical practice

Primary Outcome Measures

Name	Time	Method
Change in movement time	Baseline and 1 Day	Percentage change in time it takes to move the arm a standardized distance

Secondary Outcome Measures

Name	Time	Method
Change in maximum reaching distance	Baseline and 1 Day	Percentage change in maximum distance participant is able to reach
Change in hand path kinematics	Baseline and 1 Day	Percentage change in temporal and spatial movement of the hand during reaching

Trial Locations

Locations (1)

MedStar National Rehabilitation Hospital; 🇺🇸 Washington, District of Columbia, United States