Differential physiological and cognitive effects of an increase in daily physical activity as generated by the COACH method in healthy elderly APOE-e4 carriers and non-carriers

Clinical Neuropscyhology section, Vrije Universiteit Amsterdam0 sites266 target enrollmentTBD

ConditionsEN: Alzheimer's Disease, Inactivity, ApoE-e4, genetic vulnerability for Alzheimer's DiseaseNL: ziekte van Alzheimer, dementie, inactiviteit, ApoE-e4 dragerschap, genetische kwetsbaarheid voor Alzheimer

Overview

Phase: N/A
Intervention: Not specified
Conditions: EN: Alzheimer's Disease, Inactivity, ApoE-e4, genetic vulnerability for Alzheimer's DiseaseNL: ziekte van Alzheimer, dementie, inactiviteit, ApoE-e4 dragerschap, genetische kwetsbaarheid voor Alzheimer
Sponsor: Clinical Neuropscyhology section, Vrije Universiteit Amsterdam
Enrollment: 266
Status: Recruiting
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

n/a.

Registry

who.int

Start Date

TBD

End Date

TBD

Last Updated

2 years ago

Study Type

Interventional

Investigators

Sponsor

Clinical Neuropscyhology section, Vrije Universiteit Amsterdam

Eligibility Criteria

Inclusion Criteria

•In order to be eligible to participate in this study, participants must meet all of the following criteria: age ≥ 55 years; able to perform the Timed Up \& Go Test with or without assistive device, and a Mini Mental State Examination (Folstein, Folstein, \& McHugh, 1975\) score higher than 25\. Both males and females will be included. In the second part of the study only those participants who display low levels of physical activity as measured in Part 1 of the study are recruited.

Exclusion Criteria

•A potential subject who meets any of the following criteria will be excluded from participation in this study: wheelchair bound, cardiovascular problems that limit physical activity, epilepsy, presence of neurodegenerative disorder or focal neurological deficit, diagnosis of dementia or mild cognitive impairment, progressive or terminal disease, depression, history of alcoholism, severe visual problems, severe auditory problems and problems with the Dutch language.

Outcomes

Primary Outcomes

Not specified

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