Differential physiological and cognitive effects of the COACH method in healthy elderly APOEe4 carriers and non-carriers

Completed

Conditions: cognitive function
decline of mental functions
10012272

Registration Number: NL-OMON47735

Lead Sponsor: Vrije Universiteit

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 400

Inclusion Criteria

- Age * 55 years
- Males and females
- Able to perform the Timed Up & Go Test with or without assistive device
- Mini Mental State Examination (Folstein, Folstein, & McHugh, 1975) score higher than 25
- In the second part of the study only those participants who display low levels of physical activity as measured in Part 1 of the study are recruited and included

Exclusion Criteria

- Weelchair-bound
- diagnosed with dementia or mild cognitive impairment
- diagnosed with a neurodegenerative disease
- diagnosed with a progressive or terminal disease
- diagnosed with serious cardiovascular disease, such as heart failure that limit physical activity
- epilepsy
- (history of) substance abuse
- (history of) major psychiatric illness (e.g. depression)
- severe visual or auditory problems
- insufficient proficiency of the Dutch language

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main outcome measure is cognitive function, measured with neuropsychological<br /><br>tests. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcome measures are physical functioning measured with<br /><br>performance-based field tests, IGF-1 and BDNF serum levels, blood metabolite<br /><br>concentrations and ADLS, mood and quality of life, measured by questionnaire.</p><br>