Effect of fibrinogen on bleeding after cardiac surgery

Not Applicable

• Conditions: Condition 1: Ischemic heart diseases. Condition 2: Nonrheumatic mitral valve disorders. Condition 3: Nonrheumatic aortic valve disorders. Condition 4: Nonrheumatic tricuspid valve disorders. Condition 5: Pulmonary valve disorders. Condition 6: Rheumatic heart diseases.; Angina pectoris, unspecified; Nonrheumatic mitral valve disorders, unspecified; Nonrheumatic aortic valve disorders, unspecified; Nonrheumatic tricuspid valve disorders, unspecified; Pulmonary valve disorders, unspecified; Acute rheumatic heart disease, unspecified

• Registration Number: IRCT2013082714489N1
• Lead Sponsor: Vice chancellor for research, Mashhad university of medical sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1) Mediastinal drainage of more than 200 cc/hour after cardiac surgery, 2) Age<70 years, 3) Ejection Fraction (EF)>30% and 4) Body Mass Index (BMI)<30;
Exclusion criteria: 1) Emergency or second cardiac surgery, 2) Hemoglobin (Hb)<10, 3) platelet count<100,000/cc, and 4) Hematologic diseases

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mediastinal bleeding. Timepoint: Conducted on an hourly basis for 48 hours from the time of ICU admission after surgery (before and after the intervention). Method of measurement: Registered in the questionnaire (cc/hour).

Secondary Outcome Measures

Name	Time	Method
Mortality. Timepoint: Measured daily during the hospital stay before and after the intervention. Method of measurement: Registered in the questionnaire according to patients percentage until discharge.;ICU length of stay. Timepoint: The length of post-operative ICU stay before and after the intervention. Method of measurement: Registered in the questionnaire on a daily basis.;Blood product usage (fresh frozen plasma, platelets, packed cells, whole blood). Timepoint: Registered every 4 hours for a 48 hours period, during the post-operative ICU stay (before and after the intervention). Method of measurement: Registered in the questionnaire according to the products bag.