Combined Inspiratory Muscle and 'Whole Muscle' Training in Children With Cystic Fibrosis
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Cystic Fibrosis
- Sponsor
- Universidad Europea de Madrid
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- cardiorespiratory fitness (VO2peak)
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
To study the effects of an 8-week combined inspiratory muscle training and exercise (resistance+aerobic) program on of a lung volume, inspiratory muscle strength (maximal inspiratory pressure, PImax) and cardiorespiratory fitness (maximal oxygen uptake, VO2peak) (primary outcomes)and dynamic muscle strength, body composition and quality of life (QoL) in children with Cystic Fibrosis (CF) (secondary outcomes).
Detailed Description
The investigators hypothesized that the combined training program would significantly benefit most of the aforementioned variables (especially, primary outcomes).
Investigators
Alejandro Lucia
MD PhD
Universidad Europea de Madrid
Eligibility Criteria
Inclusion Criteria
- •boy/girl aged 6-17 years
- •living in the Madrid area
Exclusion Criteria
- •severe lung deterioration \[forced expiratory volume (FEV1) \<50% of expected\]
- •unstable clinical condition (hospitalization within the previous 3 months)
- •Burkholderia cepacia infection
- •any disorder (e.g. muscle-skeletal) impairing exercise.
Outcomes
Primary Outcomes
cardiorespiratory fitness (VO2peak)
Time Frame: this outcome will be assessed up to 12 weeks
maximum oxygen uptake (VO2peak), which is the best indicator of aerobic fitness in humans and an independent mortality predictor in children with cystic fibrosis
Secondary Outcomes
- quality of life(this outcome will be assessed up to 12 weeks)