Mesenchymal Stem Cells in Central Nervous System injury2017

Phase 1

• Conditions: Central Nervous System Injury
• Interventions: Drug: UCMSCC; Drug: conventional treatment

• Registration Number: NCT03291366
• Lead Sponsor: Fuzhou General Hospital

Brief Summary

Central nervous system (CNS) injury leads to morbidity in patients, which has few good rehabilitation measures. Mesenchymal stem cells seem to have regenerative and tissue-repairing capabilities. The investigators design this study to infuse mesenchymal stem cells (MSCs) intrathecally to CNS injury patients, and observe the safety and efficacy by recording the change of nervous system scores, trying to prove the effect of MSC in rehabilitate CNS injury.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01
• Status Verified: 2017-09
• Study First Submitted: 2017-09-20
• Study First Submitted QC: 2017-09-20
• Last Update Submitted: 2017-09-20
• Study First Posted: 2017-09-25
• Last Update Posted: 2017-09-25
• Primary Completion: 2020-01
• Study Completion: 2022-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• CNS injury > 3 months
• age > 18 years
• willing to give consent
• stable vital signs
• absence of active infectcion

Exclusion Criteria

• any contradiction to intrathecal infusion
• age < 18 years
• CNS injury < 3 months
• CNS injury > 3 years

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
MSC	UCMSCC	infusion of aUCMSC and conventional therapy
MSC	conventional treatment	infusion of aUCMSC and conventional therapy
conventional	conventional treatment	conventional therapy

Primary Outcome Measures

Name	Time	Method
life quality score	1y

Secondary Outcome Measures

Name	Time	Method
adverse events	1y