Single Neurons Responses During Visual Recognition in Epileptic Patients

Not Applicable

• Conditions: Epilepsy

• Registration Number: NCT02877576
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

The purpose is to evaluate specific capacities of face detection of individual neurons by comparison with their capacity of object detection in medial temporal lobe and ventral temporal cortex in epileptic patients.

Secondary purpose is to evaluate specific capacities of detection of known faces of individual neurons by comparison with their capacity of detection of unknown faces in medial temporal lobe and ventral temporal cortex in epileptic patients.

Detailed Description

In this interventional study, patients explored with mixed intracerebral electrodes (micro and macro-contacts) will be presented sets of images (objects, unknown faces, famous faces). Spikes and Multi-Unit-Activity will be recorded and analyzed and compared between conditions.

Study Timeline

• Study Start: 2016-05
• Study First Submitted: 2016-08-19
• Study First Submitted QC: 2016-08-23
• Study First Posted: 2016-08-24
• Status Verified: 2020-07
• Last Update Submitted: 2021-04-27
• Last Update Posted: 2021-04-28
• Primary Completion: 2023-05
• Study Completion: 2023-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Patient with temporal or occipito-temporal drug-resistant partial epilepsy, symptomatic, needing surgical treatment
• Patient having signed informed consent
• Patient affiliated to social security
• Patient having undergone preliminary medical examination

Exclusion Criteria

• Persons under legal protection or incapable to consent
• Persons deprived of liberty by juridical or administrative decision
• Patient with severe visual disorders of neurological or ophthalmological origin
• Patients with infection risk according to doctor or surgeon
• Women without effective contraception
• Pregnant or breast-feeding women

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Number of action potential (Difference of neuronal activity) generated successively by visual presentation of 60 photography of different unknown faces and 60 different objects	after electrode implantation, up to 12 days	Activity (number of action potential) is recorded for each neuron before and after visualization of each image.

Secondary Outcome Measures

Name	Time	Method
Number of action potential (Difference of neuronal activity) generated by visual presentation of 60 photography of a known target face (familiar) and 60 photography of unknown faces (non familiar)	after electrode implantation, up to 12 days	Activity (number of action potential) is recorded for each neuron before and after visualization of each image.

Trial Locations

Locations (1)

Service de Neurologie, Hôpital Central, CHRU de Nancy; 🇫🇷 Nancy, France