临床试验/NCT04324099

NCT04324099Unknown不适用

Investigating the Specificity of Neural Correlates for Emotion Processing Deficits in Conduct Disorder and Autism Spectrum Disorders

University Hospital, Basel, Switzerland1 个研究点分布在 1 个国家目标入组 120 人开始时间: 2020年7月16日最近更新: 2022年3月2日

适应症

试验速览

阶段: 不适用
发起方
入组人数: 120
试验地点: 1
主要终点: difference between groups (children and adolescents with CD, ASD and typically developing adolescents) in neural activity

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This study is

to investigate the differential and shared neural underpinnings of facial emotion processing within Conduct disorder (CD) and Autism-Spectrum disorder (ASD) and
to investigate the interaction between deficits in emotion processing and dysfunctional cognitive control processes.

Differences in emotion processing and the underlying neural underpinnings of such differences will be assessed by means of functional magnetic resonance imaging (fMRI) without any contrast agent, combined with adapted emotion processing paradigms and eye tracking techniques.

研究设计

研究类型: Observational
观察模型: Other
时间视角: Cross Sectional

入排标准

年龄范围: 10 Years 至 18 Years（Child, Adult）
性别: All
接受健康志愿者: 是

入选标准

•For all participants: age between 10 and 18 years and an intelligence quotient score of 70 or higher.
•For patient groups: confirmed clinical diagnoses according to Diagnostic and Statistical Manual (DSM)-5 of CD or ASD (depending on the group), without comorbid depression or anxiety psychological disorders.

排除标准

•For all participants: low intelligence (IQ<70, as they might otherwise not fully understand what they are expected to do inside the scanner), insufficient German language skills or any contraindications for MRI (e.g. pregnancy, any non-removable metal within the subjects' body, claustrophobia).
•For patient groups: severe developmental disorders, comorbid depressive and/or anxiety disorders will also be excluded from the study since it was shown that these patients might have problems in attention allocation under emotional stimulation.
•For typically developing participants: suspicion of an undiagnosed clinical disorder

结局指标

主要结局

difference between groups (children and adolescents with CD, ASD and typically developing adolescents) in neural activity

时间窗: fMRI imaging Day 1

difference between groups in neural activity as measured by Blood Oxygen Level Dependent (BOLD) signal during emotion processing using a priori defined regions of interest (ROIs) including the insula, amygdala, and ventromedial prefrontal Cortex in fMRI

次要结局

Emotion processing task (fMRI)(fMRI imaging Day 1)

研究者

发起方

University Hospital, Basel, Switzerland

申办方类型

Other

责任方

Sponsor

研究点 (1)

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