Effects of Different Anesthetic Gases on Hemodynamics, Arterial Oxygenation and Lung Mechanics

Completed

• Conditions: Oxygenation; Spinal Surgery

• Registration Number: NCT06118489
• Lead Sponsor: Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

Brief Summary

The bronchodilator effects of volatile anesthetics have been the subject of many clinical studies. It is known that all volatile anesthetics, especially halothane, have similar effects. Sevoflurane has been shown to reduce airway resistance more than halothane and isoflurane. Desflurane is difficult to use as an induction agent due to its harsh and extremely pungent odor and airway irritating effect. However, it has been shown that the risk of cough, respiratory arrest and laryngospasm is no different from sevoflurane when administered after intravenous induction. Although it irritates the airway, it is thought to have a bronchodilation effect as it stimulates the sympathetic system.

In spinal surgeries, prone position is required to access the operating field. When the patient is placed in the prone position, pulmonary physiology are affected. In the prone position, V/Q mismatch decreases and arterial oxygenation increases. However, lung compliance decreases and the peak inspiratory pressure required to reach the required tidal volume increases. The main purpose of this study is the effect of volatile agents on lung mechanics and oxygenisation in the prone position.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-10
• Study First Submitted: 2023-10-31
• Study First Submitted QC: 2023-10-31
• Study First Posted: 2023-11-07
• Study Start: 2023-12-01
• Primary Completion: 2024-02-01
• Study Completion: 2024-02-01
• Last Update Submitted: 2024-02-19
• Last Update Posted: 2024-02-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• 18-65 years old
• ASA1-2
• Patients planned to undergo spinal surgery

Exclusion Criteria

• 1 - Lung disease
• BMI 35 and above
• Smokers
• Those under the age of 18 and over the age of 65
• Hepatorenal disease
• Reynaud's disease
• Burger disease
• Hypotensive patient
• Neuromuscular disease
• Those who have had thoracic surgery before
• Those with bad Allen test results

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
compliance	2 hour	pulmonary compliance before, during and after prone position

Trial Locations

Locations (1)

Yadigar Yılmaz; 🇹🇷 Istanbul, Turkey