Dynamic Arterial Elastance During General Anesthesia Induction

• Conditions: Anesthesia

• Registration Number: NCT03910179
• Lead Sponsor: Università Politecnica delle Marche

Brief Summary

This study evaluates if dynamic arterial elastance measured before general anesthesia induction can predict the occurrence of hypotension due to general anesthesia induction.

Detailed Description

As general anesthetics may be responsible for vasodilation and cardiac depression, arterial hypotension after induction of general anesthesia is a common event and may contribute to an adverse outcome. Dynamic arterial elastance has been proposed as a functional parameter of arterial tone and studies showed that it was able to predict pressure response to fluid administration in fluid-responsive patients and the amount of mean arterial pressure riduction as a conseguence of noradrenaline dose reduction in critically ill patients.

Study Timeline

• Study First Submitted: 2019-04-04
• Study First Submitted QC: 2019-04-08
• Study First Posted: 2019-04-10
• Study Start: 2019-09-10
• Status Verified: 2020-03
• Last Update Submitted: 2020-03-23
• Last Update Posted: 2020-03-25
• Primary Completion: 2020-07
• Study Completion: 2021-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

• Patients that will be undergone to general anesthesia for surgery
• Patients that need mini-invasive cardiac output monitoring during surgery

Exclusion Criteria

• Age <18 yo
• Pregnancy
• Arrhythmia
• Severe valvular diseases
• Uncorrectable alterations of arterial signal

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Baseline value of Eadyn as predictor of hypotension occurrence due to general anesthesia induction	From baseline (before general anesthesia induction) up to 30 minutes.	Dynamic arterial elastance (Eadyn) will be recorded at baseline before induction of general anesthesia. Mean arterial pressure (MAP) will be recorded at baseline and continuously until tracheal intubation. The lowest value of MAP will be considered to define hypotension occurrence.

Secondary Outcome Measures

Name	Time	Method
Correlation between Eadyn and severity of hypotension due to anesthesia induction	From baseline (before general anesthesia induction) up to 30 minutes.	To evaluate the correlation between the baseline value of Eadyn and the severity of hypotension when it will occur after induction of general anesthesia

Trial Locations

Locations (1)

Azienda ospedaliero Universitaria Ospedali Riuniti Ancona; 🇮🇹 Ancona, Italy