2024-518101-18-02招募中4 期
Exploring the Pharmacomicrobiomics of Depression
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- The primary outcomes are the association between medication induced changes in gut microbial profile, depression symptoms and side effects
研究概览
简要总结
The main aim of this project is to associate the gut microbial community and treatment efficacy (i.e., relieve in symptoms and side effects) in patients with depression.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 64 years（18-64 Years）
- 接受健康志愿者
- 否
入选标准
- •Main diagnosis of unipolar depression
- •Indication for the prescription of an antidepressant
- •Starting a new SSRI/SNRI or TCA antidepressant treatment
- •Having already used one or more antidepressants without effect and/or with sideeffe
排除标准
- •Use of antibiotics in a period of three months prior to the baseline visit
- •Currently pregnant or breastfeeding
结局指标
主要结局
The primary outcomes are the association between medication induced changes in gut microbial profile, depression symptoms and side effects
The primary outcomes are the association between medication induced changes in gut microbial profile, depression symptoms and side effects
次要结局
- A secondary outcome is the role of therapeutic blood plasma levels (reflecting drug absorption) in the association between medication-induced changes in the gut microbial profile and treatment efficacy.
研究者
Mirjam Bloemendaal
Scientific
Radboud universitair medisch centrum Stichting
研究点 (1)
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