Identification of the most cost effective, microbiologically safe antimicrobial treatments for acne
Not Applicable
Completed
- Conditions
- Skin and connective tissue diseases: Skin and connective tissue diseasesSkin and Connective Tissue DiseasesAcne
- Registration Number
- ISRCTN21526350
- Lead Sponsor
- Department of Health (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 649
Inclusion Criteria
Participants were 649 people aged 12-39 years, all with mild to moderate inflammatory acne of the face.
Exclusion Criteria
Not provided at time of registration.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Proportion with at least moderate improvement in patient global self-assessment<br>2. Change in inflamed lesion count, both at 18 weeks from start of treatment
- Secondary Outcome Measures
Name Time Method The Burke and Cunliffe grade, assessor global assessment of the participant, a new acne severity score (combined assessment of inflamed lesions, non-inflamed lesions & redness of face), the Short-Form 36 questionnaire, the Dermatology Life Quality Index, the Dermatology Quality of Life questionnaire, local irritation (assessed by both participant and assessor and indirectly by use of moisturisers), the proportion of participants for whom the worst aspect of their acne had improved, re-referral rates after treatment completion, other adverse events and drop out rates, bacterial skin colonisation (with propionibacteria resistant to erythromycin, clindamycin or the tetracyclines estimated at baseline and all subsequent on treatment visits using a semi-quantitative scoring method to derive data on both prevalence and population density).