Predicting ovarian response in artificial insemination with low stimulation - PRORAILS study

Isala Klinieken0 个研究点目标入组 527 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•Subfertile couples presenting at fertility clinics with an indication for IUI in stimulated cycles: couples with unexplained or mild male subfertility and a spontaneous chance of conception below 30% (Hunault score) or higher when couples have waited for 6 months after calculation of the initial Hunault score. Unexplained subfertility including minimal to mild endometriosis (AFS grade 1 or 2) is defined as the failure to conceive after at least one year of unprotected intercourse whereas the standard fertility work-up was unable to detect any factors that might influence fertility negatively. Thus semen analysis should be normal according to the WHO guidelines and ovulation should be documented (by BBT charts, ovulation detection by ultrasound or normal luteal progesterone values). In principle, a negative history (for genital infections among others) in combination with a negative Chlamydia Antibody testing is sufficient to exclude tubal pathology. If there is any doubt or if the local protocol requires further tubal testing, a HSG, fertiloscopy or laparoscopy should be performed. Mild male subfertility is defined as abnormal semen parameters according to the WHO but an average total motile sperm account before processing of at least 10 million.

•- Hunault score * 30%
•- Endometriosis AFS grade 3 or 4
•- Contra-indications for the use of gonadotrophins (cysts larger than 2 cm, allergy for gonadotrophins)
•- Total motile sperm count after sperm processing below 1 million
•- Women aged younger than eighteen years or older than 45 years.
•- Previous treatment with COH/IUI for treating current subfertility
•- Unable to speak or read the Dutch language

发起方

Isala Klinieken