Antagonist and Short Protocols in Invitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) Cycles With Delayed Embryo Transfer in Poor Ovarian Response

Cairo University3 sites in 1 country400 target enrollmentApril 2015

ConditionsInfertility

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Infertility
Sponsor: Cairo University
Enrollment: 400
Locations: 3
Primary Endpoint: Number of good embryos
Status: Completed
Last Updated: 7 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Poor ovarian response indicates inadequate ovarian response to ovarian stimulation. In the current study the investigators will attempt to compare antagonist and short protocols regarding oocyte as well as embryo quantity and quality. Frozen embryo transfer will be performed in order to abolish iatrogenic effect of stimulation drugs on implantation. Still implantation and pregnancy rates are considered secondary outcomes.

Registry

clinicaltrials.gov

Start Date

April 2015

End Date

May 2018

Last Updated

7 years ago

Study Type

Interventional

Study Design

Parallel

Sex

Female

Investigators

Sponsor

Cairo University

Responsible Party

Principal Investigator

Yasmin Ahmed Bassiouny

Cairo University

Eligibility Criteria

Inclusion Criteria

•Patient selection is based on the ESHRE consensus group 2011 definition of poor ovarian response (POR) (Bologna criteria):
•At least two of the following three features must be present:
•Advanced maternal age (≥40 years) or any other risk factor for POR;
•A previous POR (≤3 oocytes with a conventional stimulation protocol);
•An abnormal ovarian reserve test (i.e. Antral follicle count (AFC) \<5-7 follicles or Antimullerian hormone (AMH) \<0.5-1.1 ng/ml).
•Two episodes of POR after maximal stimulation are sufficient to define a patient as poor responder in the absence of advanced maternal age or abnormal Ovarian reserve test (ORT). By definition, the term POR refers to the ovarian response and, therefore, one stimulated cycle is considered essential for the diagnosis of POR. However, patients over 40 years of age with an abnormal ORT may be classified as poor responders since both advanced age and an abnormal ORT may indicate reduced ovarian reserve and act as a surrogate of ovarian stimulation cycle. In this case, the patients should be more properly defined as expected PORs.