Assessment of Blood and Follicular Fluid Immune Cell Constitution in Patients Undergoing in Vitro Fertilization

Hillel Yaffe Medical Center1 site in 1 countryMarch 10, 2010

ConditionsInfertility, Female

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Infertility, Female
Sponsor: Hillel Yaffe Medical Center
Locations: 1
Last Updated: 16 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The etiology of infertility in the majority of patients with poor response to ovarian stimulation remains unknown. This study will investigate the role of immune cells (T cells, B cells, dendritic cells and NK cells), that constitute the immune system which normally fights infection and cancer. We, the investigators, have found that specialized NK cells that help with new blood vessel formation, are found in the fluid surrounding the egg during IVF, only in patients with good response to ovarian stimulation. We now wish to expand our studies and correlate our findings to ovarian blood flow , as measured by 3D ultrasound and to the presence of other cells in the immune system.

Registry

clinicaltrials.gov

Start Date

March 10, 2010

End Date

TBD

Last Updated

16 years ago

Study Type

Observational

Sex

Female

Investigators

Sponsor

Hillel Yaffe Medical Center

Eligibility Criteria

Inclusion Criteria

•Age 27-43 years
•Diagnosis of infertility due to endometriosis, severe male factor, tubal occlusion.
•Patient undergoing IVF

Exclusion Criteria

•Body mass index (BMI) \> 38 kg/m2
•Abnormal uterine cavity as evidenced by sonohysterogram or hysterosalpingography
•Any current use of systemic steroid medication or any infertility treatment within 3 months of study enrollment.
•Any contraindication to being pregnant and carrying a pregnancy to term.
•Any ovarian or abdominal abnormality that may interfere with adequate TVS evaluation.
•Absence of one or two ovaries
•Clinically relevant systemic disease (e.g., Insulin-dependent diabetes, adrenal dysfunction, organic intracranial lesion, polycystic ovarian syndrome, hyperprolactinemia, or hypothalamic tumor) or serious illness (Neoplasia).
•History (within past 12 months) or current abuse of alcohol or drugs.
•Administration of any investigational drugs within three months prior to study enrollment.
•Any medical condition that may interfere with the absorption, distribution, metabolism or excretion of the study drugs, gastrointestinal diseases, mal absorption syndromes and liver dysfunction