Ovulation Trigger with Less Than 3 Follicles in Stimulated In-vitro Fertilization (IVF) Cycles
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 405
- Locations
- 1
- Primary Endpoint
- Clinical Pregnancy Rate
Study Overview
Brief Summary
Poor responders in in-vitro fertilization (IVF) cycles represent a major challenge for fertility specialists. Although poor responders tend to have sub-optimal fertility treatment outcomes, many of these patients wish to attempt at least one IVF cycle. Traditionally, IVF cycles producing less than 3 to 4 mature follicles (measuring at least 14 mm) have either been cancelled or converted to intra-uterine insemination (IUI) due to the low pregnancy rates associated with these cycles. The minimal number of follicles required to proceed with egg collection is based on clinical experience, having been determined by weighing the probability of implantation and pregnancy versus the risk of not obtaining quality oocytes or reaching embryo transfer when fewer mature follicles are present. This retrospective quality control study aims to compare pregnancy rates in IVF cycles producing 3 follicles measuring 14 mm and more on trigger day, versus 2 or fewer follicles.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to 42 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Stimulated IVF cycle at clinique ovo
- •Patients with a maximum of 3 mature follicles (≥14mm) on the day of ovulation trigger
Exclusion Criteria
- •Cycle cancelation due to no follicles
- •History of recurrent implantation failure
- •Contraindication of ovulation induction medication
Outcomes
Primary Outcomes
Clinical Pregnancy Rate
Time Frame: 6 to 8 weeks after Frozen Embryo Transfer
clinical pregnancy is the presence of fetal heartbeat at the viability ultrasound
Secondary Outcomes
No secondary outcomes reported
