Importance of Left Ventricular Pacing Site in Biventricular Resynchronization Therapy for Severe Heart Failure
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Heart Failure
- Sponsor
- University Hospital, Bordeaux
- Enrollment
- 33
- Locations
- 1
- Primary Endpoint
- Variation in left ventricular dp/dt max
- Last Updated
- 18 years ago
Overview
Brief Summary
Cardiac resynchronization therapy has been shown to be effective in reducing symptoms and mortality in heart failure patients. However, very few is known about the importance of the left ventricular pacing site. We study in a random order 11 different left ventricular pacing sites and compare their hemodynamics using pressure-volume catheters. The consequences on the surface ECG are also assessed.
Detailed Description
Background. Cardiac resynchronization therapy has been shown to be effective in reducing symptoms and mortality in heart failure patients. However, very few is known about the importance of the left ventricular pacing site. Design. Single-blind, monocentric, randomized cross-over study comparing 11 left ventricular pacing sites in a random order. Intervention. Left ventricular DDD pacing on 11 ventricular sites, prior to the implantation. At each pacing site, a control hemodynamics will be obtained in AAI pacing at the same pacing rate. At each pacing site, 2 AV delays, a short and a long one, will be assessed. Eligibility criteria. Patients referred for cardiac resynchronization therapy for heart failure Outcomes. Hemodynamic measures using pressure-volume catheters.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Heart failure referred for cardiac resynchronization therapy
- •NYHA Class III or IV
- •Informed consent form signed
Exclusion Criteria
- •Hypertension not controlled by treatment
- •Coronary ischemia not controlled by treatment
Outcomes
Primary Outcomes
Variation in left ventricular dp/dt max
Secondary Outcomes
- pressures and volumes of the left ventricle
- stroke work
- surface ECG repolarisation