Impact of Catheter Ablation of Ventricular Arrhythmias on Suboptimal Biventricular Pacing in Cardiac Resynchronization Therapy
Overview
- Phase
- N/A
- Intervention
- Catheter ablation of ventricular arrhythmia
- Conditions
- Systolic Heart Failure
- Sponsor
- Universitätsklinikum Köln
- Enrollment
- 65
- Locations
- 1
- Primary Endpoint
- Percentage of Biventricular pacing
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Cardiac resynchronization therapy reduces mortality in patients with systolic heart failure and left bundle branch block. Reduced biventricular pacing can lead to therapy failure. Most effective mortality reduction was seen with a BiV pacing above 98%.
Reduced BiV pacing is a common phenomenon with potential impact on CRT-response and pts' prognosis. Frequent ventricular ectopy may be associated with attenuated benefit from CRT. The investigators sought to systematically assess the effect of ventricular arrhythmia treatment on BiV pacing.
Investigators
Eligibility Criteria
Inclusion Criteria
- •reduced biventricular pacing \<98% due to ventricular arrhythmia
Exclusion Criteria
- •reduced biventricular pacing \<98% due to other cause
- •pregnancy
Arms & Interventions
Catheter ablation group
Patients with reduced biventricular pacing due to PVC or VT receiving catheter ablation of PVC/VT according to guidelines and clinical practices
Intervention: Catheter ablation of ventricular arrhythmia
Medical treatment group
Patients with reduced biventricular pacing due to PVC or VT receiving intensified medical therapy (antiarrhythmics/betablocker) according to guidelines and clinical practices
Intervention: Intensified medical therapy
Outcomes
Primary Outcomes
Percentage of Biventricular pacing
Time Frame: 3 month after intervention biventricular pacing (%) is routinely monitored
Influence of intervention (Ablation/medical treatment) on previously reduced biventricular pacing percentage (\<98%). Biventricular pacing is measured in percentage of stimulation and is monitored at routine device interrogation.