Certain Maternal Antibodies in Relation to Doppler in Hypertension With Pregnancy

• Conditions: Pre-Eclampsia
• Interventions: Diagnostic Test: Doppler; Diagnostic Test: serum antibodies

• Registration Number: NCT03214393
• Lead Sponsor: Cairo University

Brief Summary

Relation of certain maternal serum antibodies to Doppler changes will be studied in cases suffering from hypertension with pregnancy.

Detailed Description

Assessment will be done for maternal serum anti-beta 2 glycoprotein 1 antibodies and anticardiolipin antibodies in cases of preeclampsia after 32 weeks of pregnancy. In addition, fetal Doppler changes will be assessed.

Study Timeline

• Status Verified: 2017-07
• Study First Submitted: 2017-07-10
• Study First Submitted QC: 2017-07-10
• Last Update Submitted: 2017-07-10
• Study First Posted: 2017-07-11
• Last Update Posted: 2017-07-11
• Study Start: 2017-08-01
• Primary Completion: 2018-07-30
• Study Completion: 2018-08-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

• Pregnant women 32 weeks or more gestational age
• Pre-eclampsia
• Singleton pregnancy

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Exclusion Criteria

• Intrauterine fetal death
• Fetus with apparent congenital anomalies
• Pregnant females with other medical disorders
• History of essential hypertension.
• History of antepartum hemorrhage.
• History of rupture of membranes.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Pre-Eclampsia	serum antibodies	pregnant women with Pre-Eclampsia will be assessed by serum antibodies and Doppler
Pre-Eclampsia	Doppler	pregnant women with Pre-Eclampsia will be assessed by serum antibodies and Doppler

Primary Outcome Measures

Name	Time	Method
percentage of cases that develop severe pre-eclampsia	It will be calculated after 1 year from the start of the study	percentage of cases that develop severe pre-eclampsia will be assessed by an investigator

Trial Locations

Locations (1)

Department of Obstetrics and Gynecology; 🇪🇬 Cairo, Greater Cairo, Egypt