NL-OMON47608
Completed
Phase 2
Prevention of Cerebral ischaemia in Stent Treatment for Carotid Artery Stenosis - A randomised Multi-centre phase II trial comparing Ticagrelor versus Clopidogrel with outcome assessment on MRI (PRECISE-MRI) - PRECISE-MRI
niversitätsspital Basel (USB), Departement of Neurology and Stroke Center0 sites4 target enrollmentTBD
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- carotid narrowing
- Sponsor
- niversitätsspital Basel (USB), Departement of Neurology and Stroke Center
- Enrollment
- 4
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Trial is onging in other countries
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients with symptomatic or asymptomatic atherosclerotic carotid stenosis
- •(\*50% narrowing of the lumen) in whom revascularisation of the stenosis by CAS
- •is planned routinely are eligible to participate in the study.
Exclusion Criteria
- •Contraindication against use of ASA (acetylsalicylic acid), clopidogrel, or
- •ticagrelor; anticoagulation; thrombolysis within the previous 24 hours; unable
- •to walk unassisted (modified Rankin Scale \>3\); clinically unstable; acute
- •coronary syndrome; need for any cardio\-vascular surgery or intervention, or
- •need for any other invasive procedure requiring halting of Study Medication
- •during the Study, other than the index CAS procedure for which the patient was
- •randomised; bradycardia; dyspnoea; contraindications against MRI
- •(claustrophobia, metal implants, cardiac pacemaker); or participation in
- •another intervention trial. No so\-ccalled vulnerable patients will be included.
Outcomes
Primary Outcomes
Not specified
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