The effect of nasal provocation on clinical response and nasal inflammatory parameters in nonallergic rhinitis, mixed rhinitis and allergic rhinitis patients versus healthy individuals

Conditions: non-allergic rhinitis and non-allergic nasal complaints
10046304

Registration Number: NL-OMON32628

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 80

Inclusion Criteria

male or female between 18 to 68 years of age inclusive
capable of giving written informed consent

Exclusion Criteria

Use of nasal corticosteroids within 4 weeks before participation and during study
Nasal conditions likely to effect the outcome of the study, i.e. nasal malformations
Use of intranasal medication to treat nasal symptoms
Nasal or sinussurgery in the previous three months
Use of antihistamines in the 48 hours before each visit
Recent upper airway infection
Serious or unstable co-morbidity
A diagnosis of asthma
Pregnant or lactating females
Past medical history of nasal polyposis
Smoking
Inability to follow the instructions or completing all studyprocedures

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. The difference between clinical and local inflammatory reaction to<br /><br>non-specific stimuli in nasal provocation tests in nonallergic rhinitis<br /><br>patients, mixed rhinitis patients, perennial allergic patients and healthy<br /><br>individuals<br /><br>2. The difference in reaction between nonallergic rhinitis patients, mixed<br /><br>rhinitis patients, perennial allergic patients and healthy individuals to nasal<br /><br>provocation tests<br /><br>3. The difference in reaction between chemical and physical non-specific<br /><br>stimuli and airborne allergen in nasal provocation tests in nonallergic<br /><br>rhinitis patients, mixed rhinitis patients, perennial allergic rhinitis<br /><br>patients and healthy individuals.<br /><br>4. The differences between the genetic expression profile of rhinitis at RNA<br /><br>level in nonallergic rhinitis, mixed rhinitis, allergic rhinitis patients and<br /><br>healthy individuals using the Affymetrix micro-array technology</p><br>

Secondary Outcome Measures