Neural Activations During Imaginal Exposure in Individuals Fearful of Spiders
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Blood oxygen level dependent contrast (BOLD-signal)
研究概览
简要总结
This study explores the brain basis of imaginal exposure, a widely used psychological treatment technique. Specifically, this study uses functional magnetic resonance imaging to examine brain areas activated during imaginal exposure, in individuals fearful of spiders. Physiological responses and subjective fear experienced during imaginal exposure are also assessed.
The primary aim of this study is to explore differences in neural activity during exposure to phobic, compared to neutral, mental imagery. The study will focus primarily on exploratory whole brain analyses, but will also include regions of interest analyses on brain areas previously associated with imaginal exposure. The experimental procedure consists of repeated exposure to mental imagery, i.e. imagery of short durations, including either highly emotion-provoking or neutral content, prompted by verbal instructions. A secondary aim is to explore the effects of repeated exposure to mental imagery, used during the experimental procedure, on subjective fear and physiological responses.
详细描述
Results will elucidate if neural activity to phobic imagery differs from activity associated with the production of mental imagery per se. Findings will also increase our general understanding of the neural basis of imaginal exposure treatments.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Significant fear of spiders
排除标准
- •Current psychiatric disorder other than spider phobia
- •Substance abuse
- •Neurological disease
- •Psychological treatment or psychotropic medication within six months
- •Magnetic resonance imaging contradiction
研究组 & 干预措施
Imaginal exposure
The experimental procedure consists of imaginal exposure to mental imagery of phobic and neutral stimuli, prompted through recorded verbal instructions. Participants' repeat the experimental procedure one week later in a follow-up session. Brain imaging data is only collected during day 1
干预措施: Imaginal exposure (Behavioral)
结局指标
主要结局
Blood oxygen level dependent contrast (BOLD-signal)
时间窗: Day 1
BOLD-signal is assessed using functional magnetic resonance imaging.
Physiological response during exposure to mental imagery
时间窗: Day 1
Skin-conductance responses are used as a measure of physiological response.
次要结局
- Ratings of subjective fear participants' expect to experience during exposure to mental imagery(Day 1)
- Physiological response during exposure to mental imagery(Follow-up (one week after day 1))
- Differences in physiological response during exposure to mental imagery, during day 1 compared to the follow-up session.(Difference between day 1 and the follow-up session (one week after day 1))
- Ratings of subjective fear experienced during exposure to mental imagery(Day 1)
- Spielberger State-Trait Anxiety Inventory (STAI-S)(Day 1)
- Differences in ratings of subjective fear during exposure to mental imagery, during day 1 compared to the follow-up session.(Difference between day 1 and the follow-up session (one week after day 1))
- Vividness of mental imagery(Follow-up (one week after day 1))
- Differences in vividness of mental imagery, during day 1 compared to the follow-up session.(Difference between day 1 and the follow-up session (one week after day 1))
- Difficulties in emotion regulation scale (DERS)(Day 1)