Effects of H1-Antagonist on Cognition
- Registration Number
- NCT00846950
- Lead Sponsor
- Maastricht University Medical Center
- Brief Summary
The purpose of this study is to determine whether histamine is involved in memory and specific processes in human cognition.
- Detailed Description
The neurotransmitter histamine appears to be involved in human cognitive performance. However, the exact role is very unclear. The role it plays in memory performance is highly disputed, as animal studies show decreased performance when the H1-receptor is blocked in the central nervous system while such findings in humans is scarce. To clarify the role of histamine in human memory and different processes in cognition, the effects of an H1-antagonist (dexchlorpheniramine) on memory, alertness and sensory and motor processes are measured. The study will be conducted according to a within subject cross-over design using healthy volunteers.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 18
- Healthy as determined by a physician
- present or history of any neurological of psychiatric disease
- present or history of any substance abuse
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description healthy volunteers dexchlorpheniramine, lorazepam -
- Primary Outcome Measures
Name Time Method P300 latency and LRP onset latency 1.5 hours after treatment
- Secondary Outcome Measures
Name Time Method Words recalled 1.5 hours after treatment
Trial Locations
- Locations (1)
Faculty of Psychology and Neuroscience, Maastricht University
🇳🇱Maastricht, Limburg, Netherlands