Relationship Between Cardiovascular Disease in Asthma and Eosinophil Subtypes and Biomarkers of Bronchial Remodeling.

Not yet recruiting

• Conditions: Asthma; Cardiovascular Diseases
• Interventions: Other: Asthma and cardiovascular disease

• Registration Number: NCT05589779
• Lead Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Brief Summary

To know the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease.

Detailed Description

Recent studies have shown that asthma could be a risk factor for cardiovascular disease, especially in the female and late-onset subgroups. The two entities share several risk factors, such as chronic inflammation and bronchial remodeling. Eosinophilia, characteristic of asthma, has also been described as a predictor of cardiovascular mortality.

The aim of this study is to determine the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease, as well as their relationship with eosinophil subtypes, biomarkers of chronic inflammation and bronchial remodeling.

Study Timeline

• Status Verified: 2022-10
• Study First Submitted: 2022-10-10
• Study First Submitted QC: 2022-10-18
• Last Update Submitted: 2022-10-18
• Study First Posted: 2022-10-21
• Last Update Posted: 2022-10-21
• Study Start: 2023-04-01
• Primary Completion: 2024-05-01
• Study Completion: 2024-08-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Previous diagnosis of asthma
• Signed informed consent

Exclusion Criteria

• Age under 18 years old
• Age over 99 years old
• Pneumological diseases other than asthma
• Active oncological diseases or with end of treatment <5 years
• Autoimmune or systemic inflammatory diseases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
With cardiovascular disease	Asthma and cardiovascular disease	Asthma patients with cardiovascular disease
Without cardiovascular disease	Asthma and cardiovascular disease	Asthma patients without cardiovascular disease

Primary Outcome Measures

Name	Time	Method
Clinical characteristics of patients with asthma	1 year	Spirometry with bronchodilator testing
Associated cardiovascular disease type	1 year	Cardiac infarction, stroke or peripheral artery disease

Secondary Outcome Measures

Name	Time	Method
Eosinophil subtypes	1 year	Eosinophil subtypes of patients with asthma and cardiovascular disease
Bronchial remodeling	1 year	Bronchial remodeling of patients with asthma and cardiovascular disease measured by analysis of images obtained by thoracic CT scanning
Biomarkers of chronic inflammation	1 year	Transforming growth factor-β, interleukin-5, interleukin-13, interleukin-25 and interleukin-3