Early detection and echocardiographic assessment of diabetic heart disease and the impact of neurohormonal inhibitio

Phase 2

Completed

• Conditions: Type II diabetes mellitus; Metabolic and Endocrine - Diabetes; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12610001063000
• Lead Sponsor: iverpool Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-12-02
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

Type II diabetes mellitus
Stable metabolic control

Exclusion Criteria

Severe heart failure
Chronic kidney diseases (serum creatinine > 220 umol/L)
Hyperkalaemia (serum potassium > 5 mmol/L)
Addison's disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
eft ventricular and left atrial function by echocardiogram ultrasound[Patients will be screened on enrolment before randomisation and then 12 month after enrolment];Degree of scarring of the left ventricle and left atrium by echocardiography[Patients will be screened on enrolment before randomisation and then 12 month after enrolment];Biomarkers of collagen synthesis[At baseline and at 12 months after enrolment]

Secondary Outcome Measures

Name	Time	Method
il[Nil]