DETECTION OF EARLY CARDIAC (ASYMPTOMATIC) DISEASE BY B-TYPE NATRIURETIC PEPTIDE (DETECT STUDY).
Not Applicable
Active, not recruiting
- Conditions
- Early Cardiac DiseaseCardiovascular - Other cardiovascular diseases
- Registration Number
- ACTRN12605000736640
- Lead Sponsor
- Roche Diagnostics
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Active, not recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Study Population: Fifty asymptomatic patients aged 45-65 years with treated or untreated hypertension of 10 or more years duration any of whom may or may not have additional risk factors, including diabetes, dyslipidaemia, obesity. No patient will have incurred any overt cardiovascular event (ie. no acute coronary syndrome, no stable angina, no heart failure, no cerebrovascular events and no peripheral arterial events).Control Group: Fifty age, gender and BMI-matched unmedicated controls with no history of cardiovascular risk factors or events and with normal findings on physical examination. Both groups will have normal renal function.
Exclusion Criteria
No exclusion criteria
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To test the ability of plasma NT-proBNP and/or BNP to distinguish early structural and/or functional cardiac changes (including increased left ventricular mass and abnormal diastolic function) in asymptomatic groups at risk of later adverse cardiac outcomes.[ ]
- Secondary Outcome Measures
Name Time Method