Reviving Early Diagnosis of CardioVascular Disease

Completed

• Conditions: Cardiovascular disease; coronary artery disease and heart failure); heart disease (atrial fibrillation; 10082206

• Registration Number: NL-OMON52511
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2023-03-01
• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 1278

Inclusion Criteria

1. Currently enrolled in a primary care (chronic) disease management program
for either COPD or T2D
2. Age 18 years or over
3. Willing to sign informed consent

Exclusion Criteria

1. Not proficient in Dutch or having severe cognitive impairment (i.e. not able
to understand and correctly fill in the questionnaire)
2. Having a triple diagnosis of HF, CAD and AF. Confirmed with echocardiography
in case of HF, with coronary angiography, exercise-test, stress-echo, stress
MRI, SPECT-CT/MIBI or calcium score > 100 on CT-scan in case of CAD, with
electrocardiography in case of AF.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The number of newly detected cases with CVDs (heart failure, atrial<br /><br>fibrillation or coronary artery disease) in both arms, and the subsequent<br /><br>targeted therapies these new cases received. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. the added diagnostic value of family history taking, and, in women,<br /><br>reproductive history<br /><br>2. the added diagnostic value of biomarkers other than NT-proBNP, i.e.<br /><br>high-sensitive troponine (hs-Tn), growth differentiation factor 15<br /><br>(GDF-15),ST-2?<br /><br>3. the cost-effectiveness of the Early Diagnosis Strategy compared to usual<br /><br>care</p><br>