the Influence of Different Tidal Volume to Lung Strain of ARDS Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- the strain in different tidal volume
研究概览
简要总结
Measure the lung strain in different tidal volume in ADRS patients to find the relationship between tidal volume and lung strain and find the most suitable tidal volume for each patient.
详细描述
Purpose:Find the relationship between tidal volume and lung strain in ARDS patients.Then find the most suitable tidal volume for each patient according to the dividing value.
Methods:Measure the lung strain in the tidal volume of 6mL/kg,8mL/kg,10mL/kg and 12mL/kg in each ARDS patient.
Hypothesis
With the increase of the tidal volume,the lung strain develops.In the patient with larger lung compliance,the strain of the group of conventional tidal volume is less than 0.27 and there is no obvious difference between the group of small tidal volume.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age:18-85,gender is not limited
- •Needing Invasive ventilation
- •Fit the definition of ARDS in 2012 "Berlin Definition"
- •Sign the paper of informed consent
排除标准
- •pregnancy and at the end stage of tumour
- •the COPD patients
- •less than 24h of mechanical ventilation
- •more than 5 days of mechanical ventilation
- •presence of air leaks
- •organ dysfunction and hemodynamic instability
- •including in other research
结局指标
主要结局
the strain in different tidal volume
时间窗: 2 hours
Use the GE ventilator to measure the EELV and calculate the lung strain(lung strain = VT/EELV)
次要结局
- 28 days mortality(28 days)
研究者
Xiaohua Qiu
physician
Zhongda Hospital