the Influence of Tidal Volume to Lung Strain

• Conditions: Critically Ill; Acute Respiratory Distress Syndrome

• Registration Number: NCT01864668
• Lead Sponsor: Zhongda Hospital

Brief Summary

Measure the lung strain in different tidal volume in ADRS patients to find the relationship between tidal volume and lung strain and find the most suitable tidal volume for each patient.

Detailed Description

Purpose:Find the relationship between tidal volume and lung strain in ARDS patients.Then find the most suitable tidal volume for each patient according to the dividing value.

Methods:Measure the lung strain in the tidal volume of 6mL/kg,8mL/kg,10mL/kg and 12mL/kg in each ARDS patient.

Hypothesis:With the increase of the tidal volume,the lung strain develops.In the patient with larger lung compliance,the strain of the group of conventional tidal volume is less than 0.27 and there is no obvious difference between the group of small tidal volume.

Study Timeline

• Status Verified: 2013-05
• Study First Submitted: 2013-05-21
• Study First Submitted QC: 2013-05-28
• Study First Posted: 2013-05-29
• Study Start: 2013-06
• Last Update Submitted: 2014-02-08
• Last Update Posted: 2014-02-11
• Primary Completion: 2014-03
• Study Completion: 2014-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

1. Age:18-85,gender is not limited
2. Needing Invasive ventilation
3. Fit the definition of ARDS in 2012 "Berlin Definition"
4. Sign the paper of informed consent

Exclusion Criteria

1. pregnancy and at the end stage of tumour
2. the COPD patients
3. less than 24h of mechanical ventilation
4. more than 5 days of mechanical ventilation
5. FiO2>80%
6. presence of air leaks
7. organ dysfunction and hemodynamic instability
8. including in other research

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
the strain in different tidal volume	2 hours	Use the GE ventilator to measure the EELV and calculate the lung strain(lung strain = VT/EELV)

Secondary Outcome Measures

Name	Time	Method
28 days mortality	28 days	Follow up to determine the mortality in 28 days after inclusion

Trial Locations

Locations (1)

Affiliated Zhongda Hospital of Southeast University; 🇨🇳 Nanjing, Jiangsu, China