Investigating the effect of intraovarian administration of platelet rich plasma in patients with poor ovarian response in improving the result of assisted procedures

Phase 3

Conditions: Reducedovarian reserve..
Primary ovarian failure
E28.3

Registration Number: IRCT20200905048630N5

Lead Sponsor: Bandare-abbas University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Female

Target Recruitment: 88

Inclusion Criteria

Informed consent of the patient (completion of the patient consent form by the patient or the patient's companion)
Patients aged 18 to 45 years.
Patients who have no history of ovarian surgery or ovarian endometrioma.
Normal sperm analysis
• POR (age over 40 years and/or a history of poor response to high-dose stimulation with less than three oocytes and/or adverse ovarian reserve tests including AMH < 1.1 ng/nl; AFC < 7)
Patients without endocrine disorders such as hyperprolactinemia, PCOS, etc.
Non-smoking patients
Patients who do not have cardiovascular disorders.

Exclusion Criteria

Adhesion or severe damage to the pelvis or ovaries
Immunological diseases
Hematological diseases
Platelets less than one hundred and fifty thousand per cubic millimeter
Systemic use of corticosteroids within two weeks before the procedure
Taking anticoagulants

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The number of retrieved oocytes. Timepoint: Two months after prp injection. Method of measurement: Count the number.;The number of MII oocyte obtained. Timepoint: Two months after prp injection. Method of measurement: Count the number.;Increase in AMH. Timepoint: The day of the prp injection, and then two months after the prp injection. Method of measurement: laboratory test.

Secondary Outcome Measures

Name	Time	Method
IVF cycle cancellation rate. Timepoint: Two months after PRP injection. Method of measurement: Count the number.;Clinical pregnancy rate. Timepoint: 6 weeks after embryo transfer. Method of measurement: Vaginal ultrasound.;Live birth rate. Timepoint: 9 months after embryo transfer. Method of measurement: Count the number.;Ongoing pregnancy rate. Timepoint: 20 weeks after embryo transfer. Method of measurement: Ultrasound.