Changes in vasoreactivity in migraine and syncope

• Conditions: migraine; vasovagal syncope; 10019231

• Registration Number: NL-OMON38651
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

migraine:
-migraine without aura according to the IHS criteria;
-baseline attack frequency of 1 to 8 attacks per 2 months;
-moderate or severe headache during attacks;
-age between 18 and 55 years.
-female;syncope:
-diagnosis of vasovagal syncope confirmed by a tilt table test
- attack history must include at least 5 episodes of syncope or presyncope attacks
-age between 18 and 55 years
-female;migraine and syncope:
-migraine without aura according to the IHS criteria;
-baseline attack frequency of 1 to 8 attacks per 2 months;
-moderate or severe headache during attacks;
-age between 18 and 55 years.
-female
- diagnosis of vasovagal syncope confirmed by a tilt table test or
- attack history must include at least 5 episodes of syncope or presyncopal attacks ;heathy volunteers:
-age between 18-55 years
-female

Exclusion Criteria

migraine:
-more than 10 days of headache per month;
-inability to differentiate between migraine and other forms of headache;
-pregnancy;
-current use of vasoactive medication;
-use of more than 4 units of caffeine per day during the last 14 days; ;syncope:
-inability to differentiate between vasovagal and other forms of Transient Loss of Consciousness
-pregnancy
-current use of vasoactive medication
-age beneath 18 or above 55 years
-use of more than 4 units of caffeine per day during the last 14 days;migraine en syncope:
-more than 10 days of headache per month;
-inability to differentiate between migraine and other forms of headache;
-pregnancy;
-current use of vasoactive medication;
-use of more than 4 units of caffeine per day during the last 14 days;
-inability to differentiate between vasovagal syncope and other forms of Transient Loss of Consciousness
-age beneath 18 or above 55 years;healthy volunteers:
-personal or first-degree-relative history of migraine or other primary headache syndrome, except infrequent episodic tension type headache;
- personal history of VVS or any first degree relatives with vasovagal syncope
-headache on > 2 days per month;
-pregnancy
-current use of vasoactive medication;
-use of more than 4 units of caffeine per day during the last 14 days

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>At baseline, and during admission of NTG we will measure MAP, CO, TPR, HR, CO2<br /><br>and TCD non-invasively . </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>none</p><br>