Pupillometry in Horner's Syndrome

Not Applicable

• Conditions: Horner's Syndrome; Dissection Carotid Artery; Stroke
• Interventions: Device: Automated pupillometry

• Registration Number: NCT02978079
• Lead Sponsor: University of Zurich

Brief Summary

Horner's syndrome (HS) is a result of interruption of the sympathetic innervation to the eye and ocular adnexa, which can occur due to carotid artery dissection (CAD), along which the sympathetic nerve fibers travel to reach the eye. Dissection of the carotid artery is one of the etiologies for ischemic stroke in young patients.

In our current study, we will explore the diagnostic accuracy of automated binocular pupillometry in the diagnosis or HS, and its potential in identifying dissection of the carotid artery in patients of young age who suffer ischemic stroke.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-11-28
• Study First Submitted QC: 2016-11-29
• Study First Posted: 2016-11-30
• Study Start: 2017-02-15
• Status Verified: 2021-01
• Last Update Submitted: 2021-01-08
• Last Update Posted: 2021-01-11
• Primary Completion: 2021-12-31
• Study Completion: 2022-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 135

Inclusion Criteria

• Adults 60 years of age or younger
• Acute stroke (less than 72 hours from admission)
• Informed Consent as documented by signature (Appendix Informed Consent Form)
• Ability to understand the study information and consent form

Exclusion Criteria

• known history of HS
• Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.
• Medications affecting pupillary response
• History of ocular surgery affecting the pupil

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Pupillometry in stroke patients	Automated pupillometry	All eligible patients will undergo pupillometry test for the finding of Horner's syndrome

Primary Outcome Measures

Name	Time	Method
Finding of pupillary dilation lag using pupillometry in patients with acute stroke due to carotid artery dissection	1 day of initial visit

Trial Locations

Locations (1)

Ophthalmology Department, University Hospital Zurich; 🇨🇭 Zurich, Switzerland