CTRI/2023/04/052140尚未招募Unknown
Ondansetron as an adjunctive therapy in positive, negative and cognitive symptoms of schizophrenia: A randomized double-blind placebo controlled study
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1.Inpatients satisfying the ICD 10-DCR [1993] criteria for schizophrenia
- •2.Current positive symptoms rated >=4 (moderate) on one or more of these BPRS items: conceptual disorganization, grandiosity, hallucinatory behaviour and unusual thought content.
- •3.Age 18 - 60 years of both sexes.
- •4.Illness duration of equal to or more than 2 years.
- •5.Those who give informed consent for participating in the study
排除标准
- •1.Any other major co-morbid psychiatric diagnosis and substance dependence excluding nicotine & caffeine.
- •2.Known hypersensitivity to Tab. Ondansetron or any of its components.
- •3.Receiving concomitant Apomorphine.
- •4.Deranged liver function test (Alanine transaminase >= 180 IU/l and/or Aspartate transaminase >= 140 IU/l).
- •5.Significant current/past medical or neurological illness including severe hepatic disease and history of severe head injury.
- •6.Patients who received ECT in the last 6 months or currently receiving ECT.
- •7.QTc interval >= 450ms in males and >= 470ms in females on Electrocardiogram (ECG).
- •8.Pregnancy.
研究者
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