The Effect of Intraoperative Intravenous Lidocaine Infusion on Postoperative Pain and Recovery in Children (< 7 Years Old) Undergoing Thoracoscopic Surgery:Prospective, Randomized Controlled Trial
Overview
- Phase
- Phase 4
- Intervention
- Lidocaine (drug)
- Conditions
- Pain Management After Surgery
- Sponsor
- Seoul National University Hospital
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- FLACC (ace, Legs, Activity, Cry, Consolability scale) Score
- Status
- Recruiting
- Last Updated
- 11 months ago
Overview
Brief Summary
This study aims to investigate the efficacy of intraoperative intravenous lidocaine infusion on postoperative pain management and recovery in pediatric patients undergoing thoracoscopic pulmonary resection.
Investigators
Ji-Hyun Lee
Associate Professor
Seoul National University Hospital
Eligibility Criteria
Inclusion Criteria
- •Pediatric patients aged under 7 years undergoing thoracoscopic pulmonary resection
Exclusion Criteria
- •cardiac dysfunction requiring vasopressors or inotropic agents
- •atrioventricular block or bradycardia
- •Liver or kidney dysfunction
- •Hypersensitivity to local anesthetics
Arms & Interventions
Lidocaine group
Anesthesia induction is performed according to the standard protocol. Monitoring includes electrocardiography, pulse oximetry, arterial blood pressure, depth of anesthesia (Patient State Index, PSI), and pain score (Analgesia Nociception Index). In the lidocaine group, a single bolus dose of lidocaine 1.5 mg/kg is administered concurrently with the induction of anesthesia, followed by a continuous infusion of lidocaine at a rate of 1.5 mg/kg/hr.
Intervention: Lidocaine (drug)
Control group
The control group receives a continuous infusion of normal saline in the same volume as that administered to the lidocaine group.
Intervention: Saline infusion (placebo)
Outcomes
Primary Outcomes
FLACC (ace, Legs, Activity, Cry, Consolability scale) Score
Time Frame: up to 1 hour after surgery
Highest FLACC Score recorded in the postanesthesia care unit (The scale is scored in a range of 0-10 with 0 representing no pain.)
Secondary Outcomes
- Remifentanil dose(throughout surgery (up to 3 hours))
- ANI (Analgesia Nociception Index)(throughout surgery (up to 3 hours))
- FLACC scores(6 hours, 12 hours, and 24 hours postoperatively)
- Total analgesic dosage administered postoperatively(up to 3 days after surgery)
- Postoperative complications(until discharge (up to 3-4 days after surgery))